BIOMEDICAL (MANAGEMENT/SUPPORT)

生物医学（管理/支持）

• 批准号: 8317482
• 负责人: Subha Madhavan
• 金额: $ 120万
• 依托单位: GEORGETOWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-15 至 2012-04-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8317482
• 关键词: Address; Australia; Behavioral; Blood; California; Canada; Cancer Etiology; Cancer Family; Clinic; Clinical; Clinical Pathology; Clinical Trials; Collection; Colon Carcinoma; Colorectal Cancer; Community Outreach; Consent; Data; Data Collection; Enrollment; Epidemiology; Family; Family history of; Funding; Genes; Genetic; Goals; Informatics; Institution; Interdisciplinary Study; Malignant Neoplasms; Malignant neoplasm of ovary; Medical Research; Mismatch Repair; Molecular Epidemiology; National Cancer Institute; New York City; Ontario; Outcome; Phenotype; Philadelphia; Populations at Risk; Prevention; Preventive; Preventive Intervention; Procedures; Protocols documentation; Qualifying; Recruitment Activity; Registries; Research Infrastructure; Research Personnel; Resources; Risk; Risk Factors; Site; Structure; Time; Tissue Banks; Tumor Tissue; United States National Institutes of Health; Utah; breast cancer family; breast cancer family registry; cancer risk; colon cancer family registry; data registry; gene environment interaction; genetic epidemiology; high risk; instrument; malignant breast neoplasm; meetings; multidisciplinary; neoplasm registry; population based; research study; translational study; tumor

In 1995, the National Cancer Institute funded the Breast Cancer Family Registry (Breast CFR) established at six medical research institutions from the U.S., Canada, and Australia. The six sites, including the Northern California Family Registry for Breast Cancer (NC-FRBC), have developed an infrastructure and resources to facilitate and expedite a broad spectrum of multidisciplinary research, ranging from studies of the genetics and genetic epidemiology of breast cancer, including gene-gene and gene-environment interactions, to translational studies addressing clinical, behavioral, and preventive aspects of breast cancer. At the center of this infrastructure are data and biospecimens collected from over 13,000 breast and ovarian cancer families using standardized procedures and data collection instruments. Families across a broad spectrum of breast cancer risk have been recruited through population-based cancer registries (Northern California, Ontario (Canada), and Melbourne (Australia)) and through family cancer clinics and community outreach (New York City, Philadelphia, and Utah). The Colon Cancer Family Registry (C-CFR) is a multicenter infrastructure, initiated by NIH in 1997, with a goal of accelerating multidisciplinary discoveries on colorectal cancer causes, prevention, and outcomes. Registry data and biospecimens are accessible to qualified researchers around the world. The Registry, which is now reaching maturity, is successfully meeting its mandate, as 150 collaborative projects are already underway or completed and applications for use of the Registry are increasing rapidly. Within the last ten years, the six C-CFR centers have consented and enrolled over 11,000 mostly population-based families that span the continuum from average risk through very high risk. Families are enrolled using standardized protocols for collection of family history, epidemiologic risk factors, blood collection, tumor tissue collection, and baseline phenotyping of tumors for DMA mismatch repair proficiency. Data is transmitted to a central informatics center and data from completed research studies are also transmitted, so data on each family is increasingly annotated over time.

1995年，美国国家癌症研究所资助美国、加拿大和澳大利亚的六家医学研究机构建立了乳腺癌家族登记处（Breast CFR）。包括北加州乳腺癌家庭登记处 (NC-FRBC) 在内的六个站点已经开发了基础设施和资源，以促进和加快广泛的多学科研究，范围从乳腺癌的遗传学和遗传流行病学研究，包括基因-基因和基因-环境相互作用，到解决乳腺癌临床、行为和预防方面的转化研究。该基础设施的核心是使用标准化程序和数据收集仪器从 13,000 多个乳腺癌和卵巢癌家族收集的数据和生物样本。通过基于人群的癌症登记处（北加州、安大略省（加拿大）和墨尔本（澳大利亚））以及家庭癌症诊所和社区外展（纽约市、费城和犹他州）招募了具有广泛乳腺癌风险的家庭。 结肠癌家族登记处 (C-CFR) 是一个多中心基础设施，由 NIH 于 1997 年发起，旨在加速对结直肠癌原因、预防和结果的多学科发现。世界各地合格的研究人员都可以获取注册数据和生物样本。登记处现已趋于成熟，正在成功履行其职责，因为 150 个合作项目已经在进行或已完成，并且使用登记处的申请正在迅速增加。在过去十年中，六个 C-CFR 中心已同意并登记了超过 11,000 个主要以人口为基础的家庭，这些家庭的风险范围从平均风险到极高风险。使用标准化方案对家庭进行登记，收集家族史、流行病学危险因素、血液采集、肿瘤组织采集和肿瘤基线表型分析，以提高 DMA 错配修复能力。数据被传输到中央信息中心，完成的研究数据也被传输，因此随着时间的推移，每个家庭的数据越来越多地被注释。