BIOMEDICAL (MANAGEMENT/SUPPORT)
生物医学(管理/支持)
基本信息
- 批准号:8065575
- 负责人:
- 金额:$ 94.31万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2009
- 资助国家:美国
- 起止时间:2009-05-15 至 2011-04-14
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
In 1995, the National Cancer Institute funded the Breast Cancer Family Registry (Breast CFR) established at six medical research institutions from the U.S., Canada, and Australia. The six sites, including the Northern California Family Registry for Breast Cancer (NC-FRBC), have developed an infrastructure and resources to facilitate and expedite a broad spectrum of multidisciplinary research, ranging from studies of the genetics and genetic epidemiology of breast cancer, including gene-gene and gene-environment interactions, to translational studies addressing clinical, behavioral, and preventive aspects of breast cancer. At the center of this infrastructure are data and biospecimens collected from over 13,000 breast and ovarian cancer families using standardized procedures and data collection instruments. Families across a broad spectrum of breast cancer risk have been recruited through population-based cancer registries (Northern California, Ontario (Canada), and Melbourne (Australia)) and through family cancer clinics and community outreach (New York City, Philadelphia, and Utah).
The Colon Cancer Family Registry (C-CFR) is a multicenter infrastructure, initiated by NIH in 1997, with a goal of accelerating multidisciplinary discoveries on colorectal cancer causes, prevention, and outcomes. Registry data and biospecimens are accessible to qualified researchers around the world. The Registry, which is now reaching maturity, is successfully meeting its mandate, as 150 collaborative projects are already underway or completed and applications for use of the Registry are increasing rapidly. Within the last ten years, the six C-CFR centers have consented and enrolled over 11,000 mostly population-based families that span the continuum from average risk through very high risk. Families are enrolled using standardized protocols for collection of family history, epidemiologic risk factors, blood collection, tumor tissue collection, and baseline phenotyping of tumors for DMA mismatch repair proficiency. Data is transmitted to a central informatics center and data from completed research studies are also transmitted, so data on each family is increasingly annotated over time.
1995年,美国国家癌症研究所资助了在美国六个医学研究机构建立的乳腺癌家族登记处(Breast CFR),加拿大和澳大利亚。包括北方加州乳腺癌家庭登记处(NC-FRBC)在内的六个研究中心已经开发了基础设施和资源,以促进和加快广泛的多学科研究,从乳腺癌的遗传学和遗传流行病学研究(包括基因-基因和基因-环境相互作用)到乳腺癌临床、行为和预防方面的转化研究。该基础设施的核心是使用标准化程序和数据收集工具从13,000多个乳腺癌和卵巢癌家庭收集的数据和生物标本。通过基于人群的癌症登记(北方加州、安大略(加拿大)和墨尔本(澳大利亚))以及通过家庭癌症诊所和社区外展(纽约市、费城和犹他州)招募了具有广泛乳腺癌风险的家庭。
结肠癌家族登记(C-CFR)是一个多中心的基础设施,由NIH于1997年发起,旨在加速对结直肠癌病因,预防和结局的多学科发现。世界各地的合格研究人员均可访问登记数据和生物标本。登记册现已趋于成熟,正在成功地履行其任务,因为150个合作项目已经在进行或完成,申请使用登记册的人数迅速增加。在过去的十年中,六个C-CFR中心已经同意并招募了超过11,000个主要基于人口的家庭,这些家庭跨越了从平均风险到非常高风险的连续体。使用标准化方案招募家庭,以收集家族史、流行病学风险因素、血液收集、肿瘤组织收集和用于DMA错配修复熟练度的肿瘤基线表型。数据被传输到中央信息中心,完成的研究数据也被传输,因此随着时间的推移,每个家庭的数据越来越多地被注释。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Subha Madhavan其他文献
Subha Madhavan的其他文献
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{{ truncateString('Subha Madhavan', 18)}}的其他基金
MACE2K - Molecular And Clinical Extraction: A Natural Language Processing Tool for Personalized Medicine
MACE2K - 分子和临床提取:个性化医疗的自然语言处理工具
- 批准号:
9146381 - 财政年份:2015
- 资助金额:
$ 94.31万 - 项目类别:
MACE2K - Molecular And Clinical Extraction: A Natural Language Processing Tool for Personalized Medicine
MACE2K - 分子和临床提取:个性化医疗的自然语言处理工具
- 批准号:
8874546 - 财政年份:2015
- 资助金额:
$ 94.31万 - 项目类别:
MACE2K - Molecular And Clinical Extraction: A Natural Language Processing Tool for Personalized Medicine
MACE2K - 分子和临床提取:个性化医疗的自然语言处理工具
- 批准号:
9282279 - 财政年份:2015
- 资助金额:
$ 94.31万 - 项目类别:
Informatics Support Center for the Cancer Family Registries
癌症家族登记信息学支持中心
- 批准号:
8537027 - 财政年份:2009
- 资助金额:
$ 94.31万 - 项目类别:
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