Enhancing Patient-Oriented Research and Training in OCD

拟议的职业中期研究者奖以患者为导向的研究（K24）将支持海伦布莱尔辛普森，医学博士，临床研究人员谁是致力于改善强迫症（OCD）的人的生活的职业发展。职业发展计划将提高候选人的能力1）通过接受三个特定领域的培训进行以患者为导向的研究：功能性磁共振成像，先进的统计方法和新颖的临床试验设计;和2）通过接受科学领导和文化能力的培训来指导以患者为导向的研究人员。指导计划描述了对研究员，K-获奖者和初级教师进行以患者为导向的研究的培训。在候选人的监督下，学员将获得进行以患者为导向的研究方法的实践经验，并将开发自己的独立研究方向。该研究计划包括资助的项目，重点是临床试验，但也包括神经成像和转化研究，辛普森博士与成像专家和基础科学家合作进行，使丰富的培训环境。它还包括一个新的研究项目，有两个目标：1）确定强迫症的神经认知，神经生理和神经影像生物标志物; 2）探索这些措施的表现模式是否产生了一种新的方法来分类强迫症。利用现有资源，以便在K24研究预算的限制内完成，该项目将1）加强辛普森博士的研究计划，并提高她进行以患者为导向的研究的能力; 2）为指导临床研究人员提供极好的机会。

The proposed midcareer investigator Award in Patient-Oriented Research (K24) will support the career development of Helen Blair Simpson, MD PhD, a clinical researcher who is dedicated to improving the lives of people with obsessive-compulsive disorder (OCD). The Career Development Plan will enhance the candidate's ability 1) to conduct patient-oriented research by receiving training in three specific areas: functional magnetic resonance imaging, advanced statistical methods, and novel clinical trial designs; and 2) to mentor patient-oriented researchers by receiving training in scientific leadership and cultural competence. The Mentoring Plan describes training for research fellows, K-awardees, and junior faculty in patient-oriented research. Under supervision by the candidate, mentees will obtain hand-on experience in methods for conducting patient-oriented research and will develop their own independent research directions. The Research Plan includes funded projects that focus on clinical trials but that also include neuroimaging and translational studies that Dr. Simpson conducts in collaboration with imaging experts and basic scientists, making for a rich training environment. It also includes a New Research Project with two aims: 1) to identify neurocognitive, neurophysiological, and neuroimaging biomarkers for OCD; and 2) to explore whether the pattern of performance across these measures generates a new way to classify OCD. Capitalizing on existing resources so as to be accomplished within the limits of the K24 research budget, this project will 1) enhance Dr. Simpson's research program and advance her capacity to conduct patient-oriented research; and 2) provide excellent opportunities for mentoring clinician-investigators.