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Enhancing Patient-Oriented Research and Training in OCD

加强以患者为中心的强迫症研究和培训

基本信息

批准号：
8104225
负责人：
HELEN BLAIR SIMPSON
金额：
$ 14.85万
依托单位：
COLUMBIA UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-09-01 至 2015-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8104225
关键词：
Acute Address Agonist Animal Model Anorexia Nervosa Antipsychotic Agents Anxiety Applications Grants Area Award Behavior Behavioral Biocompatible Materials Biological Markers Brain Brain imaging Budgets Characteristics Chronic Clinical Clinical Investigator Clinical Trials Clinical Trials Design Cognitive Cognitive Therapy Collaborations Corpus striatum structure Coupled DNA Development Plans Diagnosis Diet Disease Doctor of Philosophy Eating Environment Faculty Food Foundations Fright Functional Magnetic Resonance Imaging Functional disorder Funding Future Genetic Genotype Goals Grant Grouping HTR2A gene Hand Human Image Individual Intake Leadership Life Measures Mental disorders Mentors Methodology Methods Mid-Career Clinical Scientist Award (K24)Midcareer Investigator Award in Patient-Oriented Research Modeling Monoclonal Antibody R24 Motor Mus NIH Program Announcements National Institute of Mental Health Neurocognitive Nutritional Obsessive-Compulsive Disorder Outcome Parents Patients Pattern Performance Pharmaceutical Preparations Phase Pilot Projects Placebos Population Prevention Qualifying Randomized Randomized Controlled Trials Reaction Time Recruitment Activity Relapse Research Research Personnel Research Project Grants Research Support Research Training Resources Risperidone Ritual compulsion Sampling Scientist Selective Serotonin Reuptake Inhibitor Serotonin Serotonin Receptor 5-HT1B Signal Transduction Site Specificity Statistical Methods Strategic Planning Students Sum Supervision Symptoms System Techniques Testing Thalamic structure Time Training Training Programs Translational Research Treatment outcome Triad Acrylic Resin United States Food and Drug Administration Wages Work avoidance behavior base career career development clinical material clinically relevant clinically significant cultural competence design early onset evidence base experience frontal lobe gene discovery genetic association genome wide association study improved interdisciplinary approach interest mortality neural circuit neuroimaging neurophysiology novel novel strategies patient oriented patient oriented research pill prepulse inhibition prevent programs public health relevance receptor receptor binding response serotonin receptor stereotypy therapy development translational study treatment strategy

项目摘要

DESCRIPTION (provided by applicant): The proposed midcareer investigator Award in Patient-Oriented Research (K24) will support the career development of Helen Blair Simpson, MD PhD, a clinical researcher who is dedicated to improving the lives of people with obsessive-compulsive disorder (OCD). The Career Development Plan will enhance the candidate's ability 1) to conduct patient-oriented research by receiving training in three specific areas: functional magnetic resonance imaging, advanced statistical methods, and novel clinical trial designs; and 2) to mentor patient-oriented researchers by receiving training in scientific leadership and cultural competence. The Mentoring Plan describes training for research fellows, K-awardees, and junior faculty in patient-oriented research. Under supervision by the candidate, mentees will obtain hand-on experience in methods for conducting patient-oriented research and will develop their own independent research directions. The Research Plan includes funded projects that focus on clinical trials but that also include neuroimaging and translational studies that Dr. Simpson conducts in collaboration with imaging experts and basic scientists, making for a rich training environment. It also includes a New Research Project with two aims: 1) to identify neurocognitive, neurophysiological, and neuroimaging biomarkers for OCD; and 2) to explore whether the pattern of performance across these measures generates a new way to classify OCD. Capitalizing on existing resources so as to be accomplished within the limits of the K24 research budget, this project will 1) enhance Dr. Simpson's research program and advance her capacity to conduct patient-oriented research; and 2) provide excellent opportunities for mentoring clinician-investigators. PUBLIC HEALTH RELEVANCE: This is a grant application for a Midcareer Investigator Award in Patient-Oriented Research (K24) to enable Dr. Helen Blair Simpson to advance her capacity to conduct patient-oriented research and to enhance her ability to mentor clinician-investigators who seek to conduct patient-oriented research. The application is based on the candidate's interdisciplinary program focused on obsessive-compulsive disorder (OCD). It proposes a focused training program for the candidate, a plan for mentoring clinician-investigators in patient-oriented research, and a pilot project to identify biomarkers/behavioral indicators for OCD, an objective of the NIMH strategic plan.

描述（由申请人提供）：拟议的以患者为导向的研究中的职业生涯中期研究员奖（K24）将支持医学博士海伦·布莱尔·辛普森（Helen Blair Simpson）的职业发展，她是一名临床研究员，致力于改善强迫症（OCD）患者的生活。职业发展计划将增强候选人的能力：1）通过接受三个特定领域的培训来进行以患者为导向的研究：功能性磁共振成像、先进的统计方法和新颖的临床试验设计； 2）通过接受科学领导力和文化能力方面的培训来指导以患者为中心的研究人员。指导计划描述了对研究员、K-获奖者和初级教师进行以患者为导向的研究的培训。在候选人的监督下，学员将获得进行以患者为导向的研究方法的实践经验，并将开发自己的独立研究方向。该研究计划包括专注于临床试验的资助项目，但也包括辛普森博士与影像专家和基础科学家合作进行的神经影像和转化研究，从而创造了丰富的培训环境。它还包括一个新的研究项目，有两个目标：1）确定强迫症的神经认知、神经生理学和神经影像生物标志物； 2）探索这些指标的表现模式是否会产生一种新的强迫症分类方法。利用现有资源，在 K24 研究预算范围内完成，该项目将 1) 加强辛普森博士的研究计划，提高她进行以患者为导向的研究的能力； 2) 为指导临床医生-研究者提供绝佳的机会。公共健康相关性：这是一项以患者为导向的研究 (K24) 中职业生涯研究者奖的拨款申请，旨在使海伦·布莱尔·辛普森 (Helen Blair Simpson) 博士能够提高她进行以患者为导向的研究的能力，并增强她指导寻求进行以患者为导向的研究的临床医生研究人员的能力。该申请基于候选人专注于强迫症（OCD）的跨学科项目。它提出了针对候选人的重点培训计划、指导临床医生研究人员进行以患者为导向的研究的计划，以及确定强迫症生物标志物/行为指标的试点项目，这是 NIMH 战略计划的目标。