Enhancing Patient-Oriented Research and Training in OCD

描述(由申请人提供)：拟议的以患者为中心的研究生涯中期研究员奖(K24)将支持海伦·布莱尔·辛普森医学博士的职业发展，她是一名临床研究员，致力于改善强迫症(OCD)患者的生活。职业发展计划将提高候选人的能力，1)通过接受三个特定领域的培训来进行以患者为导向的研究：功能磁共振成像、先进的统计方法和新的临床试验设计；以及2)通过接受科学领导力和文化能力方面的培训来指导以患者为导向的研究人员。指导计划描述了对研究员、K奖获得者和初级教员进行的以患者为导向的研究的培训。在候选人的指导下，学员将获得进行以患者为中心的研究方法的实践经验，并将发展自己的独立研究方向。研究计划包括以临床试验为重点的资助项目，但也包括辛普森博士与成像专家和基础科学家合作开展的神经成像和翻译研究，从而创造了一个丰富的培训环境。它还包括一个新的研究项目，有两个目标：1)确定强迫症的神经认知、神经生理学和神经成像生物标志物；2)探索这些指标的表现模式是否产生了一种新的强迫症分类方法。利用现有资源，以便在K24研究预算的范围内完成，该项目将1)加强辛普森博士的研究计划，提高她进行以患者为导向的研究的能力；2)为指导临床医生和研究人员提供极好的机会。 公共卫生相关性：这是对以患者为中心的研究(K24)职业生涯中期研究员奖的拨款申请，以使海伦·布莱尔·辛普森博士能够提高她进行以患者为中心的研究的能力，并增强她指导寻求进行以患者为中心的研究的临床医生-研究人员的能力。这项申请是基于候选人针对强迫症(OCD)的跨学科项目。它提出了一项针对候选人的重点培训计划，一项在以患者为导向的研究中指导临床医生和研究人员的计划，以及一项确定强迫症生物标记物/行为指标的试点项目，这是NIMH战略计划的目标。

DESCRIPTION (provided by applicant): The proposed midcareer investigator Award in Patient-Oriented Research (K24) will support the career development of Helen Blair Simpson, MD PhD, a clinical researcher who is dedicated to improving the lives of people with obsessive-compulsive disorder (OCD). The Career Development Plan will enhance the candidate's ability 1) to conduct patient-oriented research by receiving training in three specific areas: functional magnetic resonance imaging, advanced statistical methods, and novel clinical trial designs; and 2) to mentor patient-oriented researchers by receiving training in scientific leadership and cultural competence. The Mentoring Plan describes training for research fellows, K-awardees, and junior faculty in patient-oriented research. Under supervision by the candidate, mentees will obtain hand-on experience in methods for conducting patient-oriented research and will develop their own independent research directions. The Research Plan includes funded projects that focus on clinical trials but that also include neuroimaging and translational studies that Dr. Simpson conducts in collaboration with imaging experts and basic scientists, making for a rich training environment. It also includes a New Research Project with two aims: 1) to identify neurocognitive, neurophysiological, and neuroimaging biomarkers for OCD; and 2) to explore whether the pattern of performance across these measures generates a new way to classify OCD. Capitalizing on existing resources so as to be accomplished within the limits of the K24 research budget, this project will 1) enhance Dr. Simpson's research program and advance her capacity to conduct patient-oriented research; and 2) provide excellent opportunities for mentoring clinician-investigators. PUBLIC HEALTH RELEVANCE: This is a grant application for a Midcareer Investigator Award in Patient-Oriented Research (K24) to enable Dr. Helen Blair Simpson to advance her capacity to conduct patient-oriented research and to enhance her ability to mentor clinician-investigators who seek to conduct patient-oriented research. The application is based on the candidate's interdisciplinary program focused on obsessive-compulsive disorder (OCD). It proposes a focused training program for the candidate, a plan for mentoring clinician-investigators in patient-oriented research, and a pilot project to identify biomarkers/behavioral indicators for OCD, an objective of the NIMH strategic plan.