The Mechanism of Thymic Lymphomagenesis in Genetically Engineered Mouse Model
基因工程小鼠模型胸腺淋巴瘤发生机制
基本信息
- 批准号:8349382
- 负责人:
- 金额:$ 29.82万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:
- 资助国家:美国
- 起止时间:至
- 项目状态:未结题
- 来源:
- 关键词:ActinsAmino AcidsAtypical Lymphoproliferative DisorderAutomobile DrivingBone Marrow TransplantationCellsCytokeratinEpithelial CellsFamily memberGenetically Engineered MouseGoalsHumanK-18 conjugateLarge T AntigenLymphomaLymphomagenesisMalignant NeoplasmsMammary glandMusPathway interactionsProstateProteinsRegulationSignal PathwaySimian virus 40Stromal CellsT-LymphocyteThymic epithelial cellTimeTissuescytokinelymphoblastmouse modelneoplasticoffspringtumorigenesis
项目摘要
Using T121, we generated a mouse model, in which cytokeratin (K) 18 drives floxed eGFP stop T121 expression. K18 is expressed widely in simple epithelial cells (e.g. prostate luminal cells, mammary gland luminal cells, thymic epithelial cells, etc). Once K18 mouse is crossed to a Cre line, T121 expression will be driving directly under K18 regulation. We have crossed K18 mouse to several different Cre lines (e.g. R26CreER, b-actin Cre, PbCre4, PSACre, and FSPCre). All offspring developed atypical lymphoid hyperplasia, pre-neoplastic, or T-cell lymphoblasts lymphoma. Bone marrow transplantation study showed that thymic mass was developed only in K18 recipient mice with wildtype mice as donors, and no thymic mass developed in wildtype recipient mice with K18 mice as donors, suggesting K18 stroma contribute to the lymphomagenesis in these mice.
使用T121,我们产生了小鼠模型,其中细胞角蛋白(K)18驱动floxed eGFP终止T121表达。K18广泛表达于单纯上皮细胞(如前列腺腔细胞、乳腺腔细胞、胸腺上皮细胞等)。一旦K18小鼠与Cre系杂交,T121表达将直接在K18调控下驱动。我们已经将K18小鼠与几种不同的Cre系(例如R26 CreER、b-肌动蛋白Cre、PbCre 4、PSACre和FSPCre)杂交。所有后代均发生非典型淋巴样增生、肿瘤前或T细胞淋巴母细胞淋巴瘤。骨髓移植研究表明,仅在以野生型小鼠为供体的K18受体小鼠中产生胸腺肿块,而以K18小鼠为供体的野生型受体小鼠中未产生胸腺肿块,表明K18基质有助于这些小鼠中的淋巴瘤发生。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Terry van Dyke其他文献
Terry van Dyke的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Terry van Dyke', 18)}}的其他基金
Mechanisms of Prostate Tumorigenesis Using Genetically Engineered Mouse Models
使用基因工程小鼠模型研究前列腺肿瘤发生机制
- 批准号:
8552875 - 财政年份:
- 资助金额:
$ 29.82万 - 项目类别:
The study of underlying mechanism of EGFR-Ras signaling in glioblastoma
胶质母细胞瘤中EGFR-Ras信号传导机制的研究
- 批准号:
8552936 - 财政年份:
- 资助金额:
$ 29.82万 - 项目类别:
Establishing the Preclinical Model for Metastatic Melanoma
建立转移性黑色素瘤的临床前模型
- 批准号:
8553206 - 财政年份:
- 资助金额:
$ 29.82万 - 项目类别:
Pathway Analysis in Mouse Model for Astrocytoma via Systems Biology Approach
通过系统生物学方法对星形细胞瘤小鼠模型进行通路分析
- 批准号:
8349422 - 财政年份:
- 资助金额:
$ 29.82万 - 项目类别:
Development of ESiPSC approach for non-germline GEM modelling
开发用于非种系 GEM 建模的 ESiPSC 方法
- 批准号:
8349534 - 财政年份:
- 资助金额:
$ 29.82万 - 项目类别:
Development and validation of preclinical mouse model for serous ovarian cancer
浆液性卵巢癌临床前小鼠模型的开发和验证
- 批准号:
8349495 - 财政年份:
- 资助金额:
$ 29.82万 - 项目类别:
Rb TS inhibition dedifferentiates astrocytes leading to Astrocytoma initiation
Rb TS 抑制使星形胶质细胞去分化,导致星形细胞瘤发生
- 批准号:
8763536 - 财政年份:
- 资助金额:
$ 29.82万 - 项目类别:
Pathway Analysis in Mouse Model for Astrocytoma via Systems Biology Approach
通过系统生物学方法对星形细胞瘤小鼠模型进行通路分析
- 批准号:
8938029 - 财政年份:
- 资助金额:
$ 29.82万 - 项目类别:
Development of ESiPSC approach for non-germline GEM modeling
开发用于非种系 GEM 建模的 ESiPSC 方法
- 批准号:
8938101 - 财政年份:
- 资助金额:
$ 29.82万 - 项目类别:
相似海外基金
Double Incorporation of Non-Canonical Amino Acids in an Animal and its Application for Precise and Independent Optical Control of Two Target Genes
动物体内非规范氨基酸的双重掺入及其在两个靶基因精确独立光学控制中的应用
- 批准号:
BB/Y006380/1 - 财政年份:2024
- 资助金额:
$ 29.82万 - 项目类别:
Research Grant
Quantifying L-amino acids in Ryugu to constrain the source of L-amino acids in life on Earth
量化 Ryugu 中的 L-氨基酸以限制地球生命中 L-氨基酸的来源
- 批准号:
24K17112 - 财政年份:2024
- 资助金额:
$ 29.82万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Molecular recognition and enantioselective reaction of amino acids
氨基酸的分子识别和对映选择性反应
- 批准号:
23K04668 - 财政年份:2023
- 资助金额:
$ 29.82万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Basic research toward therapeutic strategies for stress-induced chronic pain with non-natural amino acids
非天然氨基酸治疗应激性慢性疼痛策略的基础研究
- 批准号:
23K06918 - 财政年份:2023
- 资助金额:
$ 29.82万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Molecular mechanisms how arrestins that modulate localization of glucose transporters are phosphorylated in response to amino acids
调节葡萄糖转运蛋白定位的抑制蛋白如何响应氨基酸而被磷酸化的分子机制
- 批准号:
23K05758 - 财政年份:2023
- 资助金额:
$ 29.82万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Design and Synthesis of Fluorescent Amino Acids: Novel Tools for Biological Imaging
荧光氨基酸的设计与合成:生物成像的新工具
- 批准号:
2888395 - 财政年份:2023
- 资助金额:
$ 29.82万 - 项目类别:
Studentship
Collaborative Research: RUI: Elucidating Design Rules for non-NRPS Incorporation of Amino Acids on Polyketide Scaffolds
合作研究:RUI:阐明聚酮化合物支架上非 NRPS 氨基酸掺入的设计规则
- 批准号:
2300890 - 财政年份:2023
- 资助金额:
$ 29.82万 - 项目类别:
Continuing Grant
Structurally engineered N-acyl amino acids for the treatment of NASH
用于治疗 NASH 的结构工程 N-酰基氨基酸
- 批准号:
10761044 - 财政年份:2023
- 资助金额:
$ 29.82万 - 项目类别:
Lifestyle, branched-chain amino acids, and cardiovascular risk factors: a randomized trial
生活方式、支链氨基酸和心血管危险因素:一项随机试验
- 批准号:
10728925 - 财政年份:2023
- 资助金额:
$ 29.82万 - 项目类别:
Single-molecule protein sequencing by barcoding of N-terminal amino acids
通过 N 端氨基酸条形码进行单分子蛋白质测序
- 批准号:
10757309 - 财政年份:2023
- 资助金额:
$ 29.82万 - 项目类别: