AREA I BIOMOLECULAR STRUCTURE & FUNCTION: AIDS

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 关于艾滋病 第一领域的主要目标是阐明生物蛋白质的结构和功能， 分子，目的是理解和解释它们在发育中的功能 和细胞事件中。 五年续约的一项重大新举措是招募一名新的 X射线衍射蛋白质结构测定领域的教员 并提供启动资金来装备这个设施。 我们请求租用一台X光透视机 晶体学家的动机是需要补充和加强正在进行的 通过NMR进行的结构工作。 我们还做了X射线晶体分析 这是由诺华捐赠的设备，并通过学院的资金建立， 新的途径生物信息学和生物技术中心在CCNY。 生物化学和结构生物学的最新发展使I区的成员能够 进一步扩大研究领域，进入大分子和高分子 组件. 为了提高生产力和竞争力，他们必须利用新的 技术，并转向增加使用核磁共振技术结合核磁共振 这些设施是纽约市结构生物学中心不可或缺的。 符合雅阁 这个目标，我们增加了博士Sacha De Carlo，他的研究重点是3D电子 显微镜和计算机辅助图像处理来研究结构，功能和 参与基本生物过程的分子组装的动力学， 蛋白质折叠和转录。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Regarding AIDS The major Area I goals are to elucidate the structures and functions of biological molecules with the aim of understanding and explaining their functions in development and in cellular events. A major new initiative for the five-year renewal is to recruit a new faculty member in the area of X-ray diffraction for the determination of protein structure and to provide startup funds to equip this facility. Our request for the hire of an X-ray crystallographer is motivated by the need to complement and enhance the ongoing structural work carried out by NMR. We have also secured X-ray crystalography equipment which was donated by Novartis and set up through funds from the college in the new Pathways Bioinformatics and Biotechnology Center at CCNY. Recent developments in biochemistry and structural biology allow members of Area I to further expand their areas of study into large macromolecules and macromolecular assemblies. To be more productive and competitive, they must exploit the new technologies and turn to increased use of NMR techniques in conjunction with the NMR facilities that are integral to the New York City Structural Biology Center. In accord with this goal we have added Dr. Sacha De Carlo whose research focuses on 3D electron microscopy and computer-assisted image processing to study the structure, function and dynamics of molecular assemblies involved in fundamental biological processes such as protein folding and transcription.