Allopregnanolone in Short-Term Smoking Abstinence

四氢孕酮在短期戒烟中的应用

• 批准号: 8216292
• 负责人: Alicia M Allen
• 金额: $ 2.58万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-02-01 至 2013-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8216292
• 关键词: Abstinence; Acute; Addictive Behavior; Address; Allopregnanolone; Animals; Area; Behavior; Behavioral; Blood Pressure; Cigarette; Clinical; Clinical Research; Cognition; Cross-Over Studies; Crossover Design; Data; Data Analyses; Data Collection; Disease; Drug abuse; Drug usage; Estrogens; Female; Funding; Gonadal Steroid Hormones; Heart Rate; Impulsivity; Knowledge; Light; Literature; Luteal Phase; Measures; Memory; Menstrual cycle; Methodology; Moods; Morbidity - disease rate; Motivation; Motor; Neurobiology; Neurosecretory Systems; Nicotine; Nicotine Withdrawal; Participant; Patient Self-Report; Pharmaceutical Preparations; Phase; Physiological; Population; Preventive Intervention; Process; Progesterone; Randomized; Relapse; Research; Research Design; Risk; Role; Sampling; Self Administration; Serum; Severities; Sex Characteristics; Smoker; Smoking; Smoking Behavior; Smoking Cessation Intervention; Speech; Speed; Stress; Sum; Testing; Time; Tobacco; Visual; Withdrawal; Withdrawal Symptom; Woman; alcohol effect; analog; cigarette smoking; craving; depressive symptoms; disorder later incidence prevention; high risk; improved; innovation; meetings; men; mortality; multidisciplinary; neurosteroids; nicotine craving; proliferative phase Menstrual cycle; protective effect; response; sex; smoking cessation; smoking relapse

DESCRIPTION (provided by applicant): Despite the recent advancements in smoking cessation intervention treatments, the majority of smokers relapse soon after a quit attempt. Compared to men, women are at an increased risk for relapse. Although the clinical evidence is lacking, recent research suggests that allopregnanolone (ALLO) may be protective against negative drug abuse behaviors such as escalation of self-administration and severity of withdrawal symptoms. ALLO is a stress-reducing neuroactive steroid metabolized primarily from the sex hormone progesterone; therefore, in women, it varies by menstrual phase (low levels in follicular phase; high levels in luteal phase). Employing a multidisciplinary team with expertise i tobacco research, neuroendocrine response, sex hormones and analytical methodology, we will address the following project objective - investigate the role of ALLO as a possible underlying neurobiological protective factor against smoking relapse. We will achieve this objective by conducting a secondary data analyses from an ongoing study that utilizes a 2x2 randomized cross-over design to assess the role of menstrual phase and mood on short-term smoking abstinence. Our analysis will include assessment of menstrually-timed serum samples, self-reported measures of withdrawal, and response to a nicotine challenge during short-term smoking abstinence. This adjunct study provides a unique opportunity to assess our specific study aims: (1) to confirm the menstrual phase differences in systemic levels of ALLO during short-term smoking abstinence, (2) to identify the menstrual phase differences in systemic levels of ALLO in response to a nicotine challenge during short-term smoking abstinence, and (3) to determine the effect of ALLO on withdrawal symptoms and response to a nicotine challenge during short- term smoking abstinence. If funded, this project will result in new information that will shed light on the role a sex hormones metabolite, and its possible contribution in the high rates of smoking relapse among women. This information will directly inform new areas of research on smoking cessation and relapse prevention interventions. PUBLIC HEALTH RELEVANCE: This project aims to characterize the role of allopregnanolone in short-term smoking abstinence in female smokers. Allopregnanolone, a neuroactive steroid that is known to reduce stress, is metabolized from the sex hormone progesterone and may be protective against negative drug abuse behaviors such as escalation of drug use. If allopregnanolone is protective against smoking relapse, this information could be incorporated in smoking cessation interventions to improve smoking cessation rates in women.

描述(由申请人提供)：尽管戒烟干预治疗最近取得了进展，但大多数吸烟者在尝试戒烟后不久就会复发。与男性相比，女性复发的风险更高。尽管缺乏临床证据，但最近的研究表明，别孕酮(allopregnanolone，Allo)可能对自我管理升级和戒断症状严重等负面药物滥用行为具有保护作用。ALLO是一种减压神经活性类固醇，主要由性激素孕酮代谢而来；因此，在女性中，它因月经期的不同而不同(卵泡期水平较低，黄体期水平较高)。利用一个在烟草研究、神经内分泌反应、性激素和分析方法方面拥有专业知识的多学科团队，我们将致力于以下项目目标-调查Allo作为可能的潜在神经生物学保护因素对吸烟复发的作用。我们将通过从一项正在进行的研究中进行二次数据分析来实现这一目标，该研究利用2x2随机交叉设计来评估月经阶段和情绪对短期戒烟的作用。我们的分析将包括评估月经时间的血清样本，自我报告的戒烟措施，以及在短期戒烟期间对尼古丁挑战的反应。这项辅助研究为评估我们的具体研究目标提供了一个独特的机会：(1)确认短期戒烟期间ALLO系统水平的月经阶段差异，(2)确定短期戒烟期间应对尼古丁挑战的ALLO系统水平的月经阶段差异，以及(3)确定ALLO对短期戒烟期间戒断症状和尼古丁挑战的反应的影响。如果得到资助，这个项目将产生新的信息，阐明性激素代谢物的作用，以及它可能导致女性高吸烟率的原因。这些信息将直接为戒烟和预防复发干预措施研究的新领域提供信息。 公共卫生相关性：该项目旨在描述别孕酮在女性吸烟者短期戒烟中的作用。别孕酮是一种神经活性类固醇，已知可以减轻压力，由性激素孕酮代谢而来，可能对药物使用升级等负面药物滥用行为具有保护作用。如果别孕酮可以预防吸烟复发，这一信息可以被纳入戒烟干预措施，以提高女性的戒烟率。