Hormonal Response to Infant Caregiving: A Novel Strategy to Break the Opioid Relapse Cycle during the Postpartum Period
婴儿护理的荷尔蒙反应:打破产后阿片类药物复发周期的新策略
基本信息
- 批准号:10001201
- 负责人:
- 金额:$ 230.25万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-09-22 至 2025-06-30
- 项目状态:未结题
- 来源:
- 关键词:Academic achievementAddressAnxietyAwardBehavioralCannabisChildChildbirthDataDisciplineElementsEmotionalFamilyGoalsHealthHormonalHormone useHormonesHydrocortisoneInfantInterventionKnowledgeLinkMeasuresMental DepressionMethodologyMethodsMonitorMothersMotivationOpioidOutcomeOverdoseOxytocinPatternPostpartum PeriodPredictive AnalyticsPregnancyPrevalencePrevention strategyProgesteroneProspective cohort studyRelapseResearchResearch DesignRiskRisk FactorsSubstance Use DisorderSubstance of AbuseTimeWomanWorkbasecaregivingfoster carehigh rewardhigh riskillicit opioidinnovationnew technologynovel strategiesopioid useopioid use disorderpostpartum healthpreventpsychosocialrelapse riskresponsesocial
项目摘要
PROJECT SUMMARY/ABSTRACT
The prevalence of opioid use disorder (OUD) during pregnancy has increased by nearly 500% over the past 15
years. While pregnancy presents a strong motivation for seeking and complying with OUD treatment, the
postpartum period is associated with a high risk for relapse. Indeed, up to 80% of women with OUD relapse to
illicit opioid use within six months of delivery. Relapse leads to a wide range of negative health and social
outcomes for both the infant, mother, and entire family, such as physical (e.g., fatal and non-fatal overdose,
increased risk of substance use disorders in children), emotional (e.g., anxiety, depression), and social (e.g.,
foster care placement, poor academic achievement) consequences. Unfortunately, little research is available on
how to prevent postpartum opioid relapse. A wide-range of hormones (e.g., cortisol, progesterone, oxytocin)
have been linked to substance use disorders and infant caregiving activities. While hormones have the potential
to significantly reduce the risk for postpartum relapse, methodological limitations (e.g., single hormone
assessment, limited time assessment), content limitations (e.g., opioid use, polysubstance use), and a lack of
dissemination of knowledge across disciplines are all limiting this use of this potentially highly impactful
approach. Therefore, my overall goal is to use new technologies and methodologies to directly address the
current limitations and enhance the cross-discipline dissemination of knowledge to utilize hormonal
level(s)/pattern(s) to protect against opioid relapse during the high-risk postpartum period. To achieve this goal,
this New Innovator Award will address four objectives: (1) measure hormones, infant caregiving activities,
relapse risk factors, and OUD-related outcomes during the postpartum period using a prospective cohort study
design, (2) identify hormonal level(s)/pattern(s) that are predictive of postpartum opioid use via with data-driven
predictive analytics, (3) examine methods to elicit/identify targeted hormone level(s)/pattern(s) using specific
infant caregiving activities, exogenous hormone delivery, and/or continuous/frequent hormone monitoring, and
(4) preliminarily assess the link between the identified hormonal level(s)/pattern(s) and OUD-related outcomes.
Upon completion of this high-risk/high-reward project, I will either (a) be able to rule out a hormonally-based
intervention as an element of a comprehensive behavioral-psycho-social approach to prevent postpartum opioid
relapse, or (b) have strong preliminary evidence for the use of hormone level(s)/pattern(s) to prevent postpartum
opioid relapse. Further, this work will be ripe for expansion to other substances of abuse (e.g., cannabis), as well
as application to other postpartum health issues (e.g., depression, anxiety).
项目概要/摘要
过去 15 年,怀孕期间阿片类药物使用障碍 (OUD) 的患病率增加了近 500%
年。虽然怀孕是寻求和遵守 OUD 治疗的强烈动机,但
产后期与复发的高风险相关。事实上,高达 80% 的 OUD 女性会复发
分娩后六个月内非法使用阿片类药物。复发会导致广泛的健康和社会负面影响
对婴儿、母亲和整个家庭的结果,例如身体(例如致命和非致命的药物过量,
儿童物质使用障碍、情感障碍(例如焦虑、抑郁)和社交障碍(例如,
寄养安置、学业成绩不佳)后果。不幸的是,关于这方面的研究很少
如何预防产后阿片类药物复发。多种激素(例如皮质醇、黄体酮、催产素)
与物质使用障碍和婴儿护理活动有关。虽然荷尔蒙有潜力
为了显着降低产后复发的风险,方法学限制(例如单一激素
评估、限时评估)、内容限制(例如阿片类药物的使用、多物质使用)以及缺乏
跨学科的知识传播都限制了这种潜在的高度影响力的使用
方法。因此,我的总体目标是利用新技术和方法来直接解决
当前的局限性并加强知识的跨学科传播以利用荷尔蒙
防止高风险产后期间阿片类药物复发的水平/模式。为了实现这一目标,
该新创新奖将解决四个目标:(1) 测量激素、婴儿护理活动、
使用前瞻性队列研究了解产后复发风险因素和 OUD 相关结果
设计,(2) 通过数据驱动确定可预测产后阿片类药物使用的激素水平/模式
预测分析,(3)检查使用特定的方法来引发/识别目标激素水平/模式
婴儿护理活动、外源性激素输送和/或持续/频繁的激素监测,以及
(4) 初步评估已确定的激素水平/模式与 OUD 相关结果之间的联系。
完成这个高风险/高回报的项目后,我将 (a) 能够排除基于激素的
干预作为预防产后阿片类药物的综合行为-心理-社会方法的一个组成部分
复发,或 (b) 有强有力的初步证据表明可以使用激素水平/模式来预防产后
阿片类药物复发。此外,这项工作也将成熟地扩展到其他滥用物质(例如大麻)
适用于其他产后健康问题(例如抑郁、焦虑)。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Alicia M Allen其他文献
Alicia M Allen的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Alicia M Allen', 18)}}的其他基金
Evaluating Social Connectedness to Support Recovery from Opioid Use Disorder during the Postpartum Period
评估社会联系以支持产后阿片类药物使用障碍的恢复
- 批准号:
10681764 - 财政年份:2023
- 资助金额:
$ 230.25万 - 项目类别:
Testing the Feasibility of a Novel Smoking Cessation Intervention by Timing Quit Dates to Menstrual Phase in a Quitline Setting
通过在戒烟热线设置中将戒烟日期安排在月经期来测试新型戒烟干预措施的可行性
- 批准号:
9926433 - 财政年份:2018
- 资助金额:
$ 230.25万 - 项目类别:
Allopregnanolone in Short-Term Smoking Abstinence
四氢孕酮在短期戒烟中的应用
- 批准号:
8216292 - 财政年份:2012
- 资助金额:
$ 230.25万 - 项目类别:
相似海外基金
Rational design of rapidly translatable, highly antigenic and novel recombinant immunogens to address deficiencies of current snakebite treatments
合理设计可快速翻译、高抗原性和新型重组免疫原,以解决当前蛇咬伤治疗的缺陷
- 批准号:
MR/S03398X/2 - 财政年份:2024
- 资助金额:
$ 230.25万 - 项目类别:
Fellowship
Re-thinking drug nanocrystals as highly loaded vectors to address key unmet therapeutic challenges
重新思考药物纳米晶体作为高负载载体以解决关键的未满足的治疗挑战
- 批准号:
EP/Y001486/1 - 财政年份:2024
- 资助金额:
$ 230.25万 - 项目类别:
Research Grant
CAREER: FEAST (Food Ecosystems And circularity for Sustainable Transformation) framework to address Hidden Hunger
职业:FEAST(食品生态系统和可持续转型循环)框架解决隐性饥饿
- 批准号:
2338423 - 财政年份:2024
- 资助金额:
$ 230.25万 - 项目类别:
Continuing Grant
Metrology to address ion suppression in multimodal mass spectrometry imaging with application in oncology
计量学解决多模态质谱成像中的离子抑制问题及其在肿瘤学中的应用
- 批准号:
MR/X03657X/1 - 财政年份:2024
- 资助金额:
$ 230.25万 - 项目类别:
Fellowship
CRII: SHF: A Novel Address Translation Architecture for Virtualized Clouds
CRII:SHF:一种用于虚拟化云的新型地址转换架构
- 批准号:
2348066 - 财政年份:2024
- 资助金额:
$ 230.25万 - 项目类别:
Standard Grant
BIORETS: Convergence Research Experiences for Teachers in Synthetic and Systems Biology to Address Challenges in Food, Health, Energy, and Environment
BIORETS:合成和系统生物学教师的融合研究经验,以应对食品、健康、能源和环境方面的挑战
- 批准号:
2341402 - 财政年份:2024
- 资助金额:
$ 230.25万 - 项目类别:
Standard Grant
The Abundance Project: Enhancing Cultural & Green Inclusion in Social Prescribing in Southwest London to Address Ethnic Inequalities in Mental Health
丰富项目:增强文化
- 批准号:
AH/Z505481/1 - 财政年份:2024
- 资助金额:
$ 230.25万 - 项目类别:
Research Grant
ERAMET - Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
ERAMET - 快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10107647 - 财政年份:2024
- 资助金额:
$ 230.25万 - 项目类别:
EU-Funded
Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10106221 - 财政年份:2024
- 资助金额:
$ 230.25万 - 项目类别:
EU-Funded
Recite: Building Research by Communities to Address Inequities through Expression
背诵:社区开展研究,通过表达解决不平等问题
- 批准号:
AH/Z505341/1 - 财政年份:2024
- 资助金额:
$ 230.25万 - 项目类别:
Research Grant