PLASTICITY OF NON HUMAN PRIMATE TH17 CELL DIFFERENTIATION IN VITRO

非人灵长类 TH17 细胞体外分化的可塑性

基本信息

  • 批准号:
    8357347
  • 负责人:
  • 金额:
    $ 5.04万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2011
  • 资助国家:
    美国
  • 起止时间:
    2011-05-01 至 2012-04-30
  • 项目状态:
    已结题

项目摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The discovery of a new lineage of helper T cells that selectively produces interleukin (IL)-17 has provided exciting new insights into immunoregulation, host defense and the pathogenesis of autoimmune diseases. For various lung diseases, elevated Th17 cells and their secretory products, IL-17A, IL-17F are also noticed. However, the nature of the presence and the function related to IL-17 and Th17 cells remain unclear. For non-human primate, there is a lack of information on the functional roles of Th17 cells and their secretory products in various diseases and inflammatory conditions. Since non-human primate monkey is the closest animal to human, the development of Th17 cell lineage in vitro must be carried out in order to apply the new knowledge into various diseases. For Respiratory Disease Unit at CNRPC, there is an unique opportunity to utilize the adoptive transfer approach to characterize the functions of Th17 cells and their secretory products in the ongoing lung injury and asthma model, supported by NIEHS for past 30 years. The current hypothesis in the pilot project application is that the plasticity of Th17 cell lineage and function is regulated by various cytokines and mediators present in the mucosal immunity. To test this hypothesis, we will develop an in vitro system for non-human primate Th17 cell differentiation from the progenitor cells present in umbilical cord blood and to study the responses of this cell lineage to various cytokines and mediators. We believe this is the first of such a study for non-human primate Th17 cell lineage. Two specific aims are proposed. Aim 1 is to establish an in vitro culture system where non-human primate T na¿ve cells can differentiate into Th17 cell lineage. The second aim is to examine the plasticity of Th17 cell differentiation in response to various cytokines in vitro. Information obtained from these studies will serve as the basis of adoptive transfer experiments to exam the role of Th17 cells in lung diseases.
这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的, 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量, 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 选择性产生白细胞介素(IL)-17的辅助性T细胞新谱系的发现为免疫调节,宿主防御和自身免疫性疾病的发病机制提供了令人兴奋的新见解。 对于各种肺部疾病,也注意到Th 17细胞及其分泌产物IL-17 A、IL-17 F的升高。 然而,与IL-17和Th 17细胞相关的存在和功能的性质仍不清楚。 对于非人灵长类动物,缺乏关于Th 17细胞及其分泌产物在各种疾病和炎症状况中的功能作用的信息。由于非人灵长类猴是最接近人类的动物,因此必须进行Th 17细胞谱系的体外开发,以便将新知识应用于各种疾病。 对于CNRPC的呼吸系统疾病部门,有一个独特的机会利用过继转移方法来表征Th 17细胞及其分泌产物在持续肺损伤和哮喘模型中的功能,过去30年来一直得到NIEHS的支持。 目前在试点项目应用中的假设是,Th 17细胞谱系和功能的可塑性受到存在于粘膜免疫中的各种细胞因子和介质的调节。 为了验证这一假设,我们将开发一种体外系统,用于从脐带血中存在的祖细胞分化非人灵长类Th 17细胞,并研究该细胞谱系对各种细胞因子和介质的反应。 我们相信这是首次对非人灵长类Th 17细胞谱系进行此类研究。 提出了两个具体目标。 目的1是建立非人灵长类T细胞可分化为Th 17细胞谱系的体外培养体系。 第二个目的是研究Th 17细胞在体外对各种细胞因子的分化的可塑性。 从这些研究中获得的信息将作为过继转移实验的基础,以检查Th 17细胞在肺部疾病中的作用。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Reen Wu其他文献

Reen Wu的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Reen Wu', 18)}}的其他基金

Novel antimicrobials in fighting carbapenem-resistant Klebsiella pneumoniae
对抗耐碳青霉烯类肺炎克雷伯菌的新型抗菌药物
  • 批准号:
    10602594
  • 财政年份:
    2022
  • 资助金额:
    $ 5.04万
  • 项目类别:
Tackling the MARCKS-PIP3 Circuit to Attenuate Chronic Pulmonary Fibrosis
解决 MARCKS-PIP3 回路以减轻慢性肺纤维化
  • 批准号:
    10152291
  • 财政年份:
    2021
  • 资助金额:
    $ 5.04万
  • 项目类别:
Regulation of Airway Mucin Gene Expression by Epigenetic Mechanism
表观遗传机制对气道粘蛋白基因表达的调控
  • 批准号:
    8247005
  • 财政年份:
    2010
  • 资助金额:
    $ 5.04万
  • 项目类别:
Regulation of Airway Mucin Gene Expression by Epigenetic Mechanism
表观遗传机制对气道粘蛋白基因表达的调控
  • 批准号:
    8451277
  • 财政年份:
    2010
  • 资助金额:
    $ 5.04万
  • 项目类别:
PLASTICITY OF NON HUMAN PRIMATE TH17 CELL DIFFERENTIATION IN VITRO
非人灵长类 TH17 细胞体外分化的可塑性
  • 批准号:
    8172630
  • 财政年份:
    2010
  • 资助金额:
    $ 5.04万
  • 项目类别:
Regulation of Airway Mucin Gene Expression by Epigenetic Mechanism
表观遗传机制对气道粘蛋白基因表达的调控
  • 批准号:
    8050564
  • 财政年份:
    2010
  • 资助金额:
    $ 5.04万
  • 项目类别:
Regulation of Airway Mucin Gene Expression by Epigenetic Mechanism
表观遗传机制对气道粘蛋白基因表达的调控
  • 批准号:
    7918317
  • 财政年份:
    2010
  • 资助金额:
    $ 5.04万
  • 项目类别:
Regenerative Airway Epithelium by Embryonic Stem Cells
胚胎干细胞再生气道上皮
  • 批准号:
    7187990
  • 财政年份:
    2007
  • 资助金额:
    $ 5.04万
  • 项目类别:
Regenerative Airway Epithelium by Embryonic Stem Cells
胚胎干细胞再生气道上皮
  • 批准号:
    7342093
  • 财政年份:
    2007
  • 资助金额:
    $ 5.04万
  • 项目类别:
Project 2 - Postnatal Development of Pulmonary Immune Mechanisms
项目2——产后肺部免疫机制的发育
  • 批准号:
    7089293
  • 财政年份:
    2006
  • 资助金额:
    $ 5.04万
  • 项目类别:

相似海外基金

The earliest exploration of land by animals: from trace fossils to numerical analyses
动物对陆地的最早探索:从痕迹化石到数值分析
  • 批准号:
    EP/Z000920/1
  • 财政年份:
    2025
  • 资助金额:
    $ 5.04万
  • 项目类别:
    Fellowship
Animals and geopolitics in South Asian borderlands
南亚边境地区的动物和地缘政治
  • 批准号:
    FT230100276
  • 财政年份:
    2024
  • 资助金额:
    $ 5.04万
  • 项目类别:
    ARC Future Fellowships
The function of the RNA methylome in animals
RNA甲基化组在动物中的功能
  • 批准号:
    MR/X024261/1
  • 财政年份:
    2024
  • 资助金额:
    $ 5.04万
  • 项目类别:
    Fellowship
Ecological and phylogenomic insights into infectious diseases in animals
对动物传染病的生态学和系统发育学见解
  • 批准号:
    DE240100388
  • 财政年份:
    2024
  • 资助金额:
    $ 5.04万
  • 项目类别:
    Discovery Early Career Researcher Award
Zootropolis: Multi-species archaeological, ecological and historical approaches to animals in Medieval urban Scotland
Zootropolis:苏格兰中世纪城市动物的多物种考古、生态和历史方法
  • 批准号:
    2889694
  • 财政年份:
    2023
  • 资助金额:
    $ 5.04万
  • 项目类别:
    Studentship
Using novel modelling approaches to investigate the evolution of symmetry in early animals.
使用新颖的建模方法来研究早期动物的对称性进化。
  • 批准号:
    2842926
  • 财政年份:
    2023
  • 资助金额:
    $ 5.04万
  • 项目类别:
    Studentship
Study of human late fetal lung tissue and 3D in vitro organoids to replace and reduce animals in lung developmental research
研究人类晚期胎儿肺组织和 3D 体外类器官在肺发育研究中替代和减少动物
  • 批准号:
    NC/X001644/1
  • 财政年份:
    2023
  • 资助金额:
    $ 5.04万
  • 项目类别:
    Training Grant
RUI: Unilateral Lasing in Underwater Animals
RUI:水下动物的单侧激光攻击
  • 批准号:
    2337595
  • 财政年份:
    2023
  • 资助金额:
    $ 5.04万
  • 项目类别:
    Continuing Grant
RUI:OSIB:The effects of high disease risk on uninfected animals
RUI:OSIB:高疾病风险对未感染动物的影响
  • 批准号:
    2232190
  • 财政年份:
    2023
  • 资助金额:
    $ 5.04万
  • 项目类别:
    Continuing Grant
A method for identifying taxonomy of plants and animals in metagenomic samples
一种识别宏基因组样本中植物和动物分类的方法
  • 批准号:
    23K17514
  • 财政年份:
    2023
  • 资助金额:
    $ 5.04万
  • 项目类别:
    Grant-in-Aid for Challenging Research (Exploratory)
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了