PLASTICITY OF NON HUMAN PRIMATE TH17 CELL DIFFERENTIATION IN VITRO

非人灵长类 TH17 细胞体外分化的可塑性

基本信息

  • 批准号:
    8357347
  • 负责人:
  • 金额:
    $ 5.04万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2011
  • 资助国家:
    美国
  • 起止时间:
    2011-05-01 至 2012-04-30
  • 项目状态:
    已结题

项目摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The discovery of a new lineage of helper T cells that selectively produces interleukin (IL)-17 has provided exciting new insights into immunoregulation, host defense and the pathogenesis of autoimmune diseases. For various lung diseases, elevated Th17 cells and their secretory products, IL-17A, IL-17F are also noticed. However, the nature of the presence and the function related to IL-17 and Th17 cells remain unclear. For non-human primate, there is a lack of information on the functional roles of Th17 cells and their secretory products in various diseases and inflammatory conditions. Since non-human primate monkey is the closest animal to human, the development of Th17 cell lineage in vitro must be carried out in order to apply the new knowledge into various diseases. For Respiratory Disease Unit at CNRPC, there is an unique opportunity to utilize the adoptive transfer approach to characterize the functions of Th17 cells and their secretory products in the ongoing lung injury and asthma model, supported by NIEHS for past 30 years. The current hypothesis in the pilot project application is that the plasticity of Th17 cell lineage and function is regulated by various cytokines and mediators present in the mucosal immunity. To test this hypothesis, we will develop an in vitro system for non-human primate Th17 cell differentiation from the progenitor cells present in umbilical cord blood and to study the responses of this cell lineage to various cytokines and mediators. We believe this is the first of such a study for non-human primate Th17 cell lineage. Two specific aims are proposed. Aim 1 is to establish an in vitro culture system where non-human primate T na¿ve cells can differentiate into Th17 cell lineage. The second aim is to examine the plasticity of Th17 cell differentiation in response to various cytokines in vitro. Information obtained from these studies will serve as the basis of adoptive transfer experiments to exam the role of Th17 cells in lung diseases.
这个子项目是利用这些资源的众多研究子项目之一

项目成果

期刊论文数量(0)
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会议论文数量(0)
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Reen Wu其他文献

Reen Wu的其他文献

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{{ truncateString('Reen Wu', 18)}}的其他基金

Novel antimicrobials in fighting carbapenem-resistant Klebsiella pneumoniae
对抗耐碳青霉烯类肺炎克雷伯菌的新型抗菌药物
  • 批准号:
    10602594
  • 财政年份:
    2022
  • 资助金额:
    $ 5.04万
  • 项目类别:
Tackling the MARCKS-PIP3 Circuit to Attenuate Chronic Pulmonary Fibrosis
解决 MARCKS-PIP3 回路以减轻慢性肺纤维化
  • 批准号:
    10152291
  • 财政年份:
    2021
  • 资助金额:
    $ 5.04万
  • 项目类别:
Regulation of Airway Mucin Gene Expression by Epigenetic Mechanism
表观遗传机制对气道粘蛋白基因表达的调控
  • 批准号:
    8247005
  • 财政年份:
    2010
  • 资助金额:
    $ 5.04万
  • 项目类别:
Regulation of Airway Mucin Gene Expression by Epigenetic Mechanism
表观遗传机制对气道粘蛋白基因表达的调控
  • 批准号:
    8451277
  • 财政年份:
    2010
  • 资助金额:
    $ 5.04万
  • 项目类别:
PLASTICITY OF NON HUMAN PRIMATE TH17 CELL DIFFERENTIATION IN VITRO
非人灵长类 TH17 细胞体外分化的可塑性
  • 批准号:
    8172630
  • 财政年份:
    2010
  • 资助金额:
    $ 5.04万
  • 项目类别:
Regulation of Airway Mucin Gene Expression by Epigenetic Mechanism
表观遗传机制对气道粘蛋白基因表达的调控
  • 批准号:
    8050564
  • 财政年份:
    2010
  • 资助金额:
    $ 5.04万
  • 项目类别:
Regulation of Airway Mucin Gene Expression by Epigenetic Mechanism
表观遗传机制对气道粘蛋白基因表达的调控
  • 批准号:
    7918317
  • 财政年份:
    2010
  • 资助金额:
    $ 5.04万
  • 项目类别:
Regenerative Airway Epithelium by Embryonic Stem Cells
胚胎干细胞再生气道上皮
  • 批准号:
    7187990
  • 财政年份:
    2007
  • 资助金额:
    $ 5.04万
  • 项目类别:
Regenerative Airway Epithelium by Embryonic Stem Cells
胚胎干细胞再生气道上皮
  • 批准号:
    7342093
  • 财政年份:
    2007
  • 资助金额:
    $ 5.04万
  • 项目类别:
Project 2 - Postnatal Development of Pulmonary Immune Mechanisms
项目2——产后肺部免疫机制的发育
  • 批准号:
    7089293
  • 财政年份:
    2006
  • 资助金额:
    $ 5.04万
  • 项目类别:

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