Project 2 - Postnatal Development of Pulmonary Immune Mechanisms
Project 2 - Postnatal Development of Pulmonary Immune Mechanisms
批准号:
7089293
负责人:
Reen Wu
金额:
$21.52万
依托单位国家:
美国
项目类别:
财政年份:
2006
资助国家:
美国
项目状态:
已结题
起止时间:
2006-04-01 至 2011-03-31
关键词:
Macaca mulattaactive immunizationage differenceair pollutionairborne allergenasthmacell cell interactionearly experienceimmunomodulatorsjuvenile animallongitudinal animal studylung developmentmature animalmesenchymemucosal immunitynewborn animalsoxidizing agentsozonepathologic processpyroglyphidrespiratory epitheliumsmooth muscle
中文摘要
该计划自成立以来的总体目标是确定乳腺癌的病理生物学反应
英文摘要
The overall goal of this program since its inception has been to define the pathobiological response of the
mammalian respiratory system to the inhalation of ambient concentrations of oxidant air pollutants.
The focus of this renewal application will be on mechanisms of environmentally induced asthma in young
children, using the model of environmental allergic asthma in infant rhesus monkeys that we have developed
through support of this program. Using this model over the previous five years of funding, we have made a
number of startling discoveries regarding the effect of chronic ozone exposure on lung development and
growth during infancy, including: stunting of airway growth, postnatal loss of airway generations, impaired
establishment of the FGF-2 ternary signaling complex by basal cells, the failure of epithelial surfaces to
innervate, impaired central nervous control, enhancement of the allergic response, airway hyperreactivity,
disrupted alveolarization, and airway remodeling. The analytical framework in which all of the studies proposed
for this renewal will be conducted is the epithelial/mesenchymal trophic unit, whose cellular components
establish trophic interactions via an extracellular signaling complex modulated by the basement membrane
zone.
The overall hypothesis for this program is that environmental exposure to oxidant air pollutants promotes the
development of allergic asthma in the developing lungs of young children and exacerbates its severity by: (1)
disrupting the homeostasis within the epithelial/mesenchymal trophic unit and (2) fundamentally compromising
the establishment and differentiation of the trophic interactions that promote normal airway growth and
development. These changes result from the superimposition of continual cycles of acute injury, inflammation,
and repair on the immune response to allergen exposure.
This Project will focus on mucosal immunity within the epithelial/mesenchymal trophic unit, with the following
specific aims:
1) Determine how episodic ozone exposure in conjunction with sensitization to house dust mite (HDM)
allergen can initiate the asthma phenotype during postnatal development.
2) Determine how episodic ozone exposure in conjunction with sensitization to HDM allergen can contribute
to the progression of the asthma phenotype.
3) Determine how episodic ozone exposure in conjunction with sensitization to HDM allergen can result in
persistence of the asthma phenotype into early adulthood.
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会议论文
Novel antimicrobials in fighting carbapenem-resistant Klebsiella pneumoniae
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批准号:10602594
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项目类别:
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资助金额:$30.0万
-
财政年份:2022
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负责人:Reen Wu
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依托单位:
Tackling the MARCKS-PIP3 Circuit to Attenuate Chronic Pulmonary Fibrosis
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批准号:10152291
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项目类别:
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资助金额:$34.77万
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财政年份:2021
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负责人:Reen Wu
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依托单位:
PLASTICITY OF NON HUMAN PRIMATE TH17 CELL DIFFERENTIATION IN VITRO
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批准号:8357347
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项目类别:
-
资助金额:$5.04万
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财政年份:2011
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负责人:Reen Wu
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依托单位:
Regulation of Airway Mucin Gene Expression by Epigenetic Mechanism
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批准号:8247005
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项目类别:
-
资助金额:$38.08万
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财政年份:2010
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负责人:Reen Wu
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依托单位:
Regulation of Airway Mucin Gene Expression by Epigenetic Mechanism
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批准号:8451277
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项目类别:
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资助金额:$36.29万
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财政年份:2010
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负责人:Reen Wu
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依托单位:
PLASTICITY OF NON HUMAN PRIMATE TH17 CELL DIFFERENTIATION IN VITRO
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批准号:8172630
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项目类别:
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资助金额:$7.6万
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财政年份:2010
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负责人:Reen Wu
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依托单位:
Regulation of Airway Mucin Gene Expression by Epigenetic Mechanism
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批准号:8050564
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项目类别:
-
资助金额:$38.34万
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财政年份:2010
-
负责人:Reen Wu
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依托单位:
Regulation of Airway Mucin Gene Expression by Epigenetic Mechanism
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批准号:7918317
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项目类别:
-
资助金额:$38.25万
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财政年份:2010
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负责人:Reen Wu
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依托单位:
Regenerative Airway Epithelium by Embryonic Stem Cells
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批准号:7187990
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项目类别:
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资助金额:$22.77万
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财政年份:2007
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负责人:Reen Wu
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依托单位:
Regenerative Airway Epithelium by Embryonic Stem Cells
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批准号:7342093
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项目类别:
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资助金额:$19.0万
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财政年份:2007
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负责人:Reen Wu
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依托单位:
IL-17 Mediated MUC Gene Expression in Airway Epithelium
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批准号:7450970
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项目类别:
-
资助金额:$32.43万
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财政年份:2005
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负责人:Reen Wu
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依托单位:
IL-17 Mediated MUC Gene Expression in Airway Epithelium
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批准号:6930018
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项目类别:
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资助金额:$34.09万
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财政年份:2005
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负责人:Reen Wu
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依托单位:
IL-17 Mediated MUC Gene Expression in Airway Epithelium
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批准号:7038276
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项目类别:
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资助金额:$33.29万
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财政年份:2005
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负责人:Reen Wu
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依托单位:
IL-17 Mediated MUC Gene Expression in Airway Epithelium
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批准号:7242562
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项目类别:
-
资助金额:$32.43万
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财政年份:2005
-
负责人:Reen Wu
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依托单位:
Roles of IL-17-induced gene expression in airway epithelial host defense
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批准号:8253702
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项目类别:
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资助金额:$38.12万
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财政年份:2005
-
负责人:Reen Wu
-
依托单位:
Roles of IL-17-induced gene expression in airway epithelial host defense
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批准号:8461969
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项目类别:
-
资助金额:$36.29万
-
财政年份:2005
-
负责人:Reen Wu
-
依托单位:
Roles of IL-17-induced gene expression in airway epithelial host defense
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批准号:8009274
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项目类别:
-
资助金额:$38.25万
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财政年份:2005
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负责人:Reen Wu
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依托单位:
Programming Airway Epithelial Differentiation by Rad
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批准号:7086823
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项目类别:
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资助金额:$29.0万
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财政年份:2004
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负责人:Reen Wu
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依托单位:
Programming Airway Epithelial Differentiation by Rad
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批准号:7428813
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项目类别:
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资助金额:$28.16万
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财政年份:2004
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负责人:Reen Wu
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依托单位:
Programming Airway Epithelial Differentiation by Rad
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批准号:6808750
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项目类别:
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资助金额:$29.7万
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财政年份:2004
-
负责人:Reen Wu
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依托单位:
海外基金