IMMUNE ACTIVATION IN AFRICAN GREEN MONKEYS

非洲绿猴的免疫激活

• 批准号: 8358020
• 负责人: Joern E. Schmitz
• 金额: $ 6.84万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8358020
• 关键词: African; Cercopithecus pygerythrus; Chronic; Funding; Grant; HIV; Infection; National Center for Research Resources; New England; Primates; Principal Investigator; Research; Research Infrastructure; Resources; SIV; Source; United States National Institutes of Health; Virus Diseases; base; cost; cytokine; immune activation; nonhuman primate

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Simian immunodeficiency virus (SIV) is a naturally occurring infection in a wide range of African nonhuman primates, including African green monkeys (AGM), which generally results in a clinically unapparent infection. One of the major differences observed in AIDS virus infection between natural hosts of SIV and nonnatural hosts of AIDS viruses is the absence of chronic immune activation. Here we have investigated the effect experimental immune activation by repeated cytokine administrations on chronic SIVagm infection in AGM.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其他NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 猴免疫缺陷病毒（Simian immunodeficiency virus，SIV）是一种广泛存在于非洲非人灵长类动物（包括非洲绿色猴（African green monkey，AGM））中的自然感染，通常导致临床上不明显的感染。在SIV的天然宿主和AIDS病毒的非天然宿主之间观察到的AIDS病毒感染的主要差异之一是缺乏慢性免疫激活。在这里，我们研究了通过反复给予细胞因子对AGM中慢性SIVagm感染的实验性免疫激活的效果。