IMMUNE CONTROL OF SIVAGM REPLICATION IN VIVO

SIVAGM 体内复制的免疫控制

• 批准号: 8172846
• 负责人: Joern E. Schmitz
• 金额: $ 6.58万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8172846
• 关键词: African; Asians; CD8B1 gene; Cercopithecus pygerythrus; Computer Retrieval of Information on Scientific Projects Database; Disease; Funding; Grant; HIV; Human; Immune; Immune response; Infection; Institution; Lymphocyte; MS4A1 gene; Macaca; Mediating; Outcome; Research; Research Personnel; Resources; SIV; Source; United States National Institutes of Health; Viremia; Virus Diseases; in vivo; nonhuman primate

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Simian immunodeficiency virus (SIV) is a naturally occurring infection in a wide range of African nonhuman primates, including African green monkeys (AGM), which generally results in a clinically inapparent infection. In contrast, SIV infection of Asian nonhuman primates such as macaques can result in an AIDS-like disease similar to that observed in humans infected with human immunodeficiency virus (HIV). This different pathogenic outcome occurs despite similar levels of viremia. In order to evaluate the contribution of adaptive immune responses to these different outcomes, we investigated the impact of transient inhibition of CD8+ and CD20+ lymphocyte-mediated immune responses in sabaeus AGM during primary SIV infection.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 猴免疫缺陷病毒（Simian immunodeficiency virus，SIV）是一种广泛存在于非洲非人灵长类动物（包括非洲绿色猴（African green monkey，AGM））中的自然感染，通常导致临床上不明显的感染。相比之下，SIV感染亚洲非人灵长类动物，如猕猴，可导致类似于人类感染人类免疫缺陷病毒（HIV）的艾滋病样疾病。尽管病毒血症水平相似，但仍发生这种不同的致病结果。为了评估适应性免疫应答对这些不同结果的贡献，我们研究了在SIV初次感染期间，对Sabaeus AGM中CD 8+和CD 20+淋巴细胞介导的免疫应答的短暂抑制的影响。