CD8 LYMPHOCYTE RESPONSES IN SIV PATHOGENESIS

描述（来自摘要）：原发性HIV-1中病毒复制的控制 感染和感染后的疾病与 CD 8 + T淋巴细胞反应。这种CD 8+淋巴细胞的核心作用 介导的细胞免疫应答在控制病毒复制中的作用， 直接用猕猴的猿免疫缺陷病毒证明 （SIVmac）/恒河猴艾滋病模型。然而，更详细的描述 CD 8+淋巴细胞介导的解剖分布和功能是 对于制定预防或治疗HIV-1感染的战略至关重要。在 特别是，病毒复制的控制机制， 这些病毒特异性CD 8+淋巴细胞在各种组织中的解剖分布 淋巴组织和这些细胞对艾滋病的潜在贡献 发病机制尚未完全了解。 这是一个修改后的申请，建议探索解剖分布 SIV特异性CTL的表达及CD 8+淋巴细胞在SIV免疫发病机制中的作用 CD 4 +T细胞在艾滋病病毒感染中的下降。具体地说， 1.描述SIVmac特异性CD 8 + T淋巴细胞的解剖分布， 原发性感染， 2.确定CD 8+淋巴细胞对CD 4 + T细胞损失的贡献 在感染SIVmac或快速CD 4 +T细胞耗竭病毒后， SHIV-KB 9。

DESCRIPTION (from abstract): The control of virus replication in primary HIV-1 infection and disease following infection are correlated with the magnitude of the CD8+ T lymphocyte response. The central role of this CD8+ lymphocyte mediated cellular immune response in controlling virus replication has recently been demonstrated directly using the simian immunodeficiency virus of macaques (SIVmac)/rhesus monkey model of AIDS. However, a more detailed characterization of the anatomic distribution and functions mediated by CD8+ lymphocytes is essential for developing strategies to prevent or treat HIV-1 infection. In particular, the mechanism by which virus replication is controlled, the anatomic distribution of these virus-specific CD8+ lymphocytes among various lymphoid tissues and the potential contribution of these cells to AIDS pathogenesis are not fully understood. This is an amended application proposing to explore the anatomic distribution of SIV-specific CTL and the role of CD8+lymphocytes in the immunopathogenesis of CD4+T cell decline in AIDS virus infection. Specifically, 1. Describe the anatomic distribution of SIVmac-specific CD8+ T lymphocytes in primary infection and 2. Determine the contribution of CD8+ lymphocytes to the loss of CD4+ Tcells following infection by SIVmac or the rapidly CD4+T cell-depleting virus SHIV-KB9.