NANOFIBER NERVE GUIDE CONDUITS FOR REPAIR OF SPINAL INJURY IN NONHUMAN PRIMATES

用于修复非人类灵长类动物脊柱损伤的纳米纤维神经导管

• 批准号: 8357369
• 负责人: LEIF A HAVTON
• 金额: $ 4.86万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357369
• 关键词: Animals; Behavioral; California; Cauda Equina; Funding; GDNF gene; Grant; Hindlimb; Image; Injection of therapeutic agent; Injury; Magnetic Resonance Imaging; National Center for Research Resources; Nerve; Nerve Root Avulsions; Operative Surgical Procedures; Paresis; Primates; Principal Investigator; Research; Research Infrastructure; Resources; Roentgen Rays; Source; Spinal Injuries; Tracer; Training; United States National Institutes of Health; conus medullaris; cost; nanofiber; nonhuman primate; repaired

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Use of GDNF-Releasing Nanofiber Nerve Guide Conduits for the Repair of Conus Medullaris/Cauda Equina Injury in the Non-Human Primate. All animals will undergo Xray and MRI imaging, behavioral recordings, treadmill training, a surgery to cause a lumosacral nerve root avulsion as well as post-surgical tracer and anatomical marker injections. After the lumbosacral nerve root avulsion, four of the five groups will also undergo a surgical therapy to hopefully ameliorate the expected hindlimb paresis caused by the surgery.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其他NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 使用GDNF释放纳米纤维神经导管修复非人灵长类动物的脊髓圆锥/马尾损伤。所有动物将接受X射线和MRI成像、行为记录、跑步机训练、导致腰骶神经根撕脱的手术以及术后示踪剂和解剖标记物注射。在腰骶神经根撕脱后，五组中的四组还将接受手术治疗，以有望改善手术引起的预期后肢轻瘫。