PATHOGENESIS OF ORAL RHESUS LYMPHOCRYPTOVIRUS INFECTION

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 恒河猴口腔淋巴隐病毒感染的发病机制 本研究的总体目标是了解裂解病毒复制在免疫活性和免疫抑制宿主急性EBV感染中的作用。 该提案包括以下具体目标： 具体目标#1 -免疫活性恒河猴经口接种后，病毒复制在原发性rhLCV感染中的作用是什么？ 具体目标#2 -经口接种SHIV免疫抑制恒河猴后，病毒复制在原发性rhLCV感染中的作用是什么？ 具体目标#3 -在急性rhLCV感染中，对裂解蛋白具有特异性的CD 8 + CTL多早出现？ 这些研究将阐明裂解性病毒复制的作用和急性感染期间的免疫应答， 否则很难或不可能在人类身上进行研究。更好地理解溶解性蛋白质与 EBV感染和对裂解性EBV蛋白的免疫应答将有助于开发新的治疗药物， 用于控制EBV感染和与裂解性EBV复制相关的疾病的方法，例如口腔毛状疱疹， 白斑病

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Pathogenesis of oral rhesus lymphocryptovirus infection The overall goal of this study is understand the role of lytic viral replication during acute EBV infection of immunocompetent and immunosuppressed hosts. The proposal includes the following specific aims: Specific Aim #1 - What is the role of viral replication in primary rhLCV infection after oral inoculation of immunocompetent rhesus macaques? Specific Aim #2 - What is the role of viral replication in primary rhLCV infection after oral inoculation of SHIV immunosuppressed rhesus macaques? Specific aim #3 - How early do CD8+ CTL specific for lytic proteins develop in acute rhLCV infection? These studies will elucidate the role of lytic viral replication and the immune response during acute infection that would otherwise be difficult, or impossible, to study in humans. A better understanding of the interplay between lytic EBV infection and the immune response to lytic EBV proteins will contribute to development of novel therapeutic approaches for control of EBV infection and diseases associated with lytic EBV replication, such as oral hairy leukoplakia.