PATHOGENESIS OF ORAL RHESUS LYMPHOCRYPTOVIRUS INFECTION

口腔恒河猴淋巴细胞病毒感染的发病机制

• 批准号: 8172865
• 负责人: Frederick C. Wang
• 金额: $ 6.58万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8172865
• 关键词: Acute; CD8B1 gene; Computer Retrieval of Information on Scientific Projects Database; Development; Disease; Epstein-Barr Virus Infections; Funding; Goals; Grant; Hairy Leukoplakia; Human; Immune response; Immunocompetent; Immunocompromised Host; Infection; Institution; Lymphocryptovirus; Lytic; Macaca mulatta; Oral; Pathogenesis; Proteins; Research; Research Personnel; Resources; Role; Source; United States National Institutes of Health; Viral; immunosuppressed; lytic replication; novel therapeutic intervention; simian human immunodeficiency virus

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall goal of this study is understand the role of lytic viral replication during acute EBV infection of immunocompetent and immunosuppressed hosts. The proposal includes the following specific aims: Specific Aim #1 - What is the role of viral replication in primary rhLCV infection after oral inoculation of immunocompetent rhesus macaques? Specific Aim #2 - What is the role of viral replication in primary rhLCV infection after oral inoculation of SHIV immunosuppressed rhesus macaques? Specific aim #3 - How early do CD8+ CTL specific for lytic proteins develop in acute rhLCV infection? These studies will elucidate the role of lytic viral replication and the immune response during acute infection that would otherwise be difficult, or impossible, to study in humans. A better understanding of the interplay between lytic EBV infection and the immune response to lytic EBV proteins will contribute to development of novel therapeutic approaches for control of EBV infection and diseases associated with lytic EBV replication, such as oral hairy leukoplakia.

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本研究的总体目标是了解裂解病毒复制在免疫活性和免疫抑制宿主急性EBV感染中的作用。 该提案包括以下具体目标： 具体目标#1 -免疫活性恒河猴经口接种后，病毒复制在原发性rhLCV感染中的作用是什么？ 具体目标#2 -经口接种SHIV免疫抑制恒河猴后，病毒复制在原发性rhLCV感染中的作用是什么？ 具体目标#3 -在急性rhLCV感染中，对裂解蛋白具有特异性的CD 8 + CTL多早出现？ 这些研究将阐明裂解性病毒复制的作用和急性感染期间的免疫应答， 否则很难或不可能在人类身上进行研究。更好地理解溶解性蛋白质与 EBV感染和对裂解性EBV蛋白的免疫应答将有助于开发新的治疗药物， 用于控制EBV感染和与裂解性EBV复制相关的疾病的方法，例如口腔毛状疱疹， 白斑病