ANOPHELES SRPN6 FUNCTIONS DURING MALARIA PARASITE INVASION OF MOSQUITO EPITHELIA
按蚊 SRPN6 在疟疾寄生虫侵入蚊子上皮期间的功能
基本信息
- 批准号:8360337
- 负责人:
- 金额:$ 18.07万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2011
- 资助国家:美国
- 起止时间:2011-07-01 至 2013-06-30
- 项目状态:已结题
- 来源:
- 关键词:AfricanAnopheles GenusAnopheles gambiaeBiteBloodCommunicable DiseasesComplexCulicidaeDevelopmentDiseaseEpithelialEpitheliumEventFemaleFundingGrantHealthHumanImmune responseImmunityIndividualInfectionInterventionKnowledgeMalariaMeasuresMidgutNational Center for Research ResourcesOrganParasitesPlasmodium falciparumPreventionPrincipal InvestigatorRegulationResearchResearch InfrastructureResourcesSalivary GlandsSerine Proteinase InhibitorsSerpinsSourceUnited States National Institutes of Healthcostdesigninsightnovelparasite invasionprotein functiontransmission processvectorvector mosquito
项目摘要
This subproject is one of many research subprojects utilizing the resources
provided by a Center grant funded by NIH/NCRR. Primary support for the subproject
and the subproject's principal investigator may have been provided by other sources,
including other NIH sources. The Total Cost listed for the subproject likely
represents the estimated amount of Center infrastructure utilized by the subproject,
not direct funding provided by the NCRR grant to the subproject or subproject staff.
Despite ongoing control and prevention efforts, malaria remains one of the most devastating infectious diseases, world-wide. Female Anopheles mosquitoes are the carriers (vectors) for human malaria. When a mosquito bites an infected individual, it takes up infectious forms of the malaria parasite along with blood. The parasite undergoes a complex journey through its mosquito vector, before it can subsequently be injected into the next human host via mosquito bite. As part of this journey, the parasite must cross the linings (epithelia) of two mosquito organs, the midgut and the salivary glands. Both crossing events are central to the successful development of the parasite within the mosquito. This study aims to gain insight into how these mosquito epithelia react and potentially limit malaria parasite infection in the natural parasite/vector combination that most important to human health: the African malaria mosquito, Anopheles gambiae and the human malaria parasite, Plasmodium falciparum. The specific hypothesis of this project is that An. gambiae midgut and salivary glands mount a common immune response against parasite invasion, which is characterized by serpin-6 (SRPN6), a protein that functions as a serine protease inhibitor. Our aims are to (a) explore the regulation of SRPN6 during the invasion of the midgut and salivary glands by the parasite and (b) to measure any potential effect of SRPN6 on the passage of the parasite through these epithelia. The results of this study can provide important clues to the potential contribution of epithelial immunity to parasite transmission by mosquito vectors in a disease-relevant mosquito/parasite combination. Such knowledge could potentially be used to design novel malaria intervention strategies, in which the parasite transmission cycle in the mosquito.
这个子项目是许多利用资源的研究子项目之一
由NIH/NCRR资助的中心拨款提供。子项目的主要支持
而子项目的主要调查员可能是由其他来源提供的,
包括其他NIH来源。 列出的子项目总成本可能
代表子项目使用的中心基础设施的估计数量,
而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。
尽管不断作出控制和预防努力,但疟疾仍然是世界范围内最具破坏性的传染病之一。雌性按蚊是人类疟疾的携带者。当蚊子叮咬受感染的个体时,它沿着血液携带疟疾寄生虫的传染形式。这种寄生虫通过其蚊子载体经历了一个复杂的旅程,然后可以通过蚊子叮咬将其注入下一个人类宿主。在这个过程中,寄生虫必须穿过蚊子两个器官的内层(上皮),即中肠和唾液腺。这两个交叉事件是蚊子体内寄生虫成功发育的关键。本研究旨在深入了解这些蚊子上皮细胞如何反应,并可能限制疟疾寄生虫感染的自然寄生虫/载体组合,最重要的是人类健康:非洲疟疾蚊子,冈比亚按蚊和人类疟疾寄生虫,恶性疟原虫。该项目的具体假设是,安。冈比亚中肠和唾液腺对寄生虫入侵产生共同的免疫应答,其特征在于丝氨酸蛋白酶抑制剂6(SRPN 6),一种起丝氨酸蛋白酶抑制剂作用的蛋白质。我们的目的是(a)探索SRPN 6在寄生虫入侵中肠和唾液腺期间的调节和(B)测量SRPN 6对寄生虫通过这些上皮的任何潜在作用。这项研究的结果可以提供重要的线索,在疾病相关的蚊子/寄生虫组合的蚊子媒介的寄生虫传播的上皮免疫的潜在贡献。这些知识有可能被用来设计新的疟疾干预策略,其中寄生虫在蚊子中的传播周期。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Kristin Michel其他文献
Kristin Michel的其他文献
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{{ truncateString('Kristin Michel', 18)}}的其他基金
The protease network that regulates innate immunity in mosquitoes
调节蚊子先天免疫的蛋白酶网络
- 批准号:
10454962 - 财政年份:2018
- 资助金额:
$ 18.07万 - 项目类别:
The protease network that regulates innate immunity in mosquitoes
调节蚊子先天免疫的蛋白酶网络
- 批准号:
10232089 - 财政年份:2018
- 资助金额:
$ 18.07万 - 项目类别:
Vector Biology Representation at the 2014 Arthropod Genomics Symposium
2014 年节肢动物基因组学研讨会上的媒介生物学代表
- 批准号:
8720366 - 财政年份:2014
- 资助金额:
$ 18.07万 - 项目类别:
The function(s) of serpin-2 in mosquito immunity and physiology
Serpin-2 在蚊子免疫和生理学中的功能
- 批准号:
8259121 - 财政年份:2011
- 资助金额:
$ 18.07万 - 项目类别:
The function(s) of serpin-2 in mosquito immunity and physiology
Serpin-2 在蚊子免疫和生理学中的功能
- 批准号:
8645605 - 财政年份:2011
- 资助金额:
$ 18.07万 - 项目类别:
The function(s) of serpin-2 in mosquito immunity and physiology
Serpin-2 在蚊子免疫和生理学中的功能
- 批准号:
8458144 - 财政年份:2011
- 资助金额:
$ 18.07万 - 项目类别:
The function(s) of serpin-2 in mosquito immunity and physiology
Serpin-2 在蚊子免疫和生理学中的功能
- 批准号:
8163820 - 财政年份:2011
- 资助金额:
$ 18.07万 - 项目类别:
ANOPHELES SRPN6 FUNCTIONS DURING MALARIA PARASITE INVASION OF MOSQUITO EPITHELIA
按蚊 SRPN6 在疟疾寄生虫侵入蚊子上皮期间的功能
- 批准号:
8167828 - 财政年份:2010
- 资助金额:
$ 18.07万 - 项目类别:
ANOPHELES SRPN6 FUNCTIONS DURING MALARIA PARASITE INVASION OF MOSQUITO EPITHELIA
按蚊 SRPN6 在疟疾寄生虫侵入蚊子上皮期间的功能
- 批准号:
7959798 - 财政年份:2009
- 资助金额:
$ 18.07万 - 项目类别: