COBRE: UNE MED CTR: CORE B: MOUSE GENOME ENGINEERING

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 这项科布雷提案的一个目标是将UNMC-Creighton-Boys镇NRH三角形建立为 公认的神经感觉发育研究卓越中心。带着所有人的承诺 三大机构向人类保健，小鼠将是未来最重要的模式生物 关于这个主题的生物医学研究。因此，鼠标核心的存在和可用性将不会 只有通过现场建立相关鼠标才能使最初的Cobre调查人员受益 模特，但一旦最初的Cobre调查人员轮流离开，将作为必要的招聘工具 新的调查人员将被带上船。我们预计，这些新人也将专注于 老鼠，使用基因操纵的老鼠来推进他们的研究。特别是，初级调查人员 对MICE经验有限的客户将从Mouse核心支持服务中受益匪浅。 此外，我们预计该提案的几个项目的表情特征实验 将产生值得为新的转基因和基因敲除小鼠模型生成的结果 以研究它们在神经感觉发育中的功能。因此，我们是 相信鼠标内核的推出将显著增强新产品的竞争力 由这项科布雷提案推动的外部资金申请。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. One goal of this COBRE proposal is to establish the triangle UNMC-Creighton-Boys Town NRH as a recognized Center of Research Excellence in Neurosensory Development. With the commitment of all three institutions to human health care, the mouse will be the paramount model organism for future biomedical research on this topic. The presence and availability of a Mouse Core will, therefore, not only benefit the initial COBRE Investigators through the on-site establishment of the pertinent mouse models, but will serve as an essential recruiting tool once the initial COBRE Investigators will rotate off and new Investigators will be brought aboard. We anticipate that such recruits will also focus on the mouse, use genetically manipulated mice to advance their research. In particular, junior Investigators with limited experience with mice would greatly benefit from Mouse Core support services. Furthermore, we expect that the expression profiling experiments of several projects of this proposal will yield results that merit the generation of new transgenic and knockout mouse models for the respective genes in order to study their function in neurosensory development. We are therefore convinced that the availability of a Mouse Core will significantly enhance the competitiveness of new applications for extramural funding that are fostered by this COBRE proposal.