TISSUE BIOREPOSITORY

组织生物样本库

• 批准号: 8360358
• 负责人: DAVID N REISMAN
• 金额: $ 12.02万
• 依托单位: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2013-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8360358
• 关键词: Biological Models; Clinical; Clinical Data; Colon Carcinoma; Core Facility; Diagnostic; Funding; Genetic; Grant; Human; Institutional Review Boards; Lead; Malignant Neoplasms; Modeling; Molecular; National Center for Research Resources; Operative Surgical Procedures; Outcome; Primary Neoplasm; Principal Investigator; Research; Research Infrastructure; Research Personnel; Resources; Source; Specimen; Therapeutic; Tissues; Tumor-Derived; United States National Institutes of Health; anticancer research; base; biobank; cost; human tissue; innovation; population based; prognostic; tissue culture; tumor progression

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. While significant progress in understanding the molecular basis of cancer and cancer progression has been made though the use of tissue culture model systems, these models have clear limitations. The use of human specimens derived from donor matched sets, such as primary tumor and normal adjacent tissue, combined with information of clinical status and outcome, can provide both genetic and population-based information that could be critical for the facilitation of innovation in diagnostics, prognostics and therapeutics as well as towards the understanding of underlying mechanisms that lead to cancer. The Tissue Biorepository is a newly organized Core Facility of the Center for Colon Cancer Research. It is an IRB-approved biorepository that collects and banks excess surgical specimens. The objective of the Biorepository is to facilitate cancer research by providing high quality normal and tumor-derived human tissue along with robust clinical data to researchers.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 虽然通过使用组织培养模型系统在理解癌症和癌症进展的分子基础方面取得了显著进展，但这些模型具有明显的局限性。 使用来自供体匹配集的人类标本，如原发性肿瘤和正常邻近组织，结合临床状态和结果的信息，可以提供遗传和基于人群的信息，这些信息对于促进诊断学、免疫学和治疗学的创新以及理解导致癌症的潜在机制至关重要。 组织生物库是结肠癌研究中心新组建的核心设施。 这是一个IRB批准的生物储存库，收集和储存多余的手术标本。生物库的目标是通过向研究人员提供高质量的正常和肿瘤来源的人体组织沿着强大的临床数据来促进癌症研究。