COBRE: UL: ADMIN CORE: MOLECULAR DETERMINANTS OF DEVELOPMENTAL DEFECTS

COBRE：UL：管理核心：发育缺陷的分子决定因素

• 批准号: 8360167
• 负责人: ROBERT M GREENE
• 金额: $ 48.71万
• 依托单位: UNIVERSITY OF LOUISVILLE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8360167
• 关键词: Area; Biomedical Research; Centers of Research Excellence; Congenital Abnormality; Defect; Development; Discipline; Equipment; Extramural Activities; Faculty; Fostering; Funding; Goals; Grant; Health; Medicine; Mentors; Molecular; National Center for Research Resources; Principal Investigator; Public Health; Research; Research Infrastructure; Research Personnel; Research Proposals; Resources; School Dentistry; Scientist; Series; Signal Transduction; Source; United States National Institutes of Health; Universities; base; career development; cost; expectation; flexibility; member; programs; success

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. DESCRIPTION (provided by applicant): The purpose of this application for a Center of Biomedical Research Excellence (COBRE) is to foster health-related research and increase the competitiveness of junior, unfunded investigators at the Birth Defects Center at the UL School of Dentistry for independent funding. This COBRE augments and strengthens the biomedical research capacity at the Birth Defects Center through provision of flexible support to expand and develop biomedical faculty research capability. The program is led by an established biomedical research scientist, well recognized for his extensive expertise central to the research theme of the proposal. The COBRE supports junior investigators from several complementary disciplines, each of whom is mentored by an established, well-funded senior biomedical research faculty member, recognized for his/her scientific expertise in the area of the junior investigator's research proposal. This approach is a critical assurance of success of this initiative. This COBRE represents an integrated series of studies focusing on two common themes - molecular mechanisms of birth defects and cellular signal transduction - that encompass a number of diverse scientific disciplines. Faculty from the Schools of Dentistry, Medicine and Public Health, representing a multiplicity of scientific disciplines, present a multifunctional approach to questions of the molecular basis of developmental anomalies. The COBRE substantially enhances the development of eight young investigators with outstanding potential to develop into competitive, independent and collaborative investigators. A detailed plan for their research career development has been formulated, expectations and goals for achieving extramural support is outlined, the extent of departmental and university support provided to these junior faculty is substantial, clear and tangible evidence of institutional commitment has been documented, and sufficient and adequate space and equipment resources for the conduct of the proposed studies exists.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 子项目的主要研究者可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 描述（由申请人提供）：本申请生物医学研究卓越中心（COBRE）的目的是促进与健康相关的研究，并提高UL牙科学院出生缺陷中心的初级，无资金研究人员的竞争力。该COBRE通过提供灵活的支持来扩大和发展生物医学系的研究能力，从而增强和加强了出生缺陷中心的生物医学研究能力。该计划由一位成熟的生物医学研究科学家领导，他以其广泛的专业知识而闻名，这些专业知识对该提案的研究主题至关重要。COBRE支持来自几个互补学科的初级研究人员，每个人都由一位已建立的，资金充足的高级生物医学研究教员指导，该教员因其在初级研究人员研究提案领域的科学专业知识而受到认可。这种做法是这一举措取得成功的关键保证。这个COBRE代表了一个综合系列的研究，重点是两个共同的主题-出生缺陷的分子机制和细胞信号转导-包括一些不同的科学学科。 来自牙科，医学和公共卫生学院的教师，代表了多个科学学科，提出了一种多功能的方法来解决发育异常的分子基础问题。COBRE大大促进了八名年轻调查员的发展，他们具有出色的潜力，可以发展成为有竞争力、独立和协作的调查员。他们的研究职业发展的详细计划已经制定，实现校外支持的期望和目标的概述，部门和大学的支持提供给这些初级教师的程度是大量的，明确和有形的证据机构的承诺已被记录在案，和足够的空间和设备资源进行拟议的研究存在。