COBRE: UL: ADMIN CORE: MOLECULAR DETERMINANTS OF DEVELOPMENTAL DEFECTS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 描述（由申请人提供）：本申请生物医学研究卓越中心（COBRE）的目的是促进与健康相关的研究，并提高UL牙科学院出生缺陷中心的初级，无资金研究人员的竞争力。如果获得资助，该COBRE将通过提供灵活的支持来扩大和发展生物医学系的研究能力，从而增强和加强出生缺陷中心的生物医学研究能力。该计划由一位成熟的生物医学研究科学家领导，他以其广泛的专业知识而闻名，这些专业知识对该提案的研究主题至关重要。该应用程序寻求从几个互补学科的初级研究人员的支持，其中每个人都将由一个既定的，资金充足的高级生物医学研究教员指导，承认他/她在初级研究人员的研究建议领域的科学专业知识。这种做法是这一举措取得成功的关键保证。该应用程序代表了一个综合系列的研究，重点是两个共同的主题-出生缺陷和细胞信号转导的分子机制-包括一些不同的科学学科。来自牙科，医学，护理，工程学院和艺术与科学学院的教师，代表了多个科学学科，提出了一种多功能的方法来解决发育异常的分子基础问题。这项申请如果获得资助，将大大促进11名年轻研究人员的发展，他们具有出色的潜力，可以发展成为具有竞争力、独立和协作性的研究人员。他们的研究职业发展的详细计划已经制定，实现校外支持的期望和目标的概述，部门和大学的支持提供给这些初级教师的程度是大量的，明确和有形的证据机构的承诺已被记录在案，和足够的空间和设备资源进行拟议的研究存在。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. DESCRIPTION (provided by applicant): The purpose of this application for a Center of Biomedical Research Excellence (COBRE) is to foster health-related research and increase the competitiveness of junior, unfunded investigators at the Birth Defects Center at the UL School of Dentistry for independent funding. If funded, this COBRE will augment and strengthen the biomedical research capacity at the Birth Defects Center through provision of flexible support to expand and develop biomedical faculty research capability. The program is led by an established biomedical research scientist, well recognized for his extensive expertise central to the research theme of the proposal. The application seeks support for junior investigators from several complementary disciplines, each of whom will be mentored by an established, well-funded senior biomedical research faculty member, recognized for his/her scientific expertise in the area of the junior investigator's research proposal. This approach is a critical assurance of success of this initiative. This application represents an integrated series of studies focusing on two common themes - molecular mechanisms of birth defects and cellular signal transduction - that encompass a number of diverse scientific disciplines. Faculty from the Schools of Dentistry, Medicine, Nursing, Engineering and the College of Arts and Sciences, representing a multiplicity of scientific disciplines, present a multifunctional approach to questions of the molecular basis of developmental anomalies. This application, if funded, will substantially enhance the development of eleven young investigators with outstanding potential to develop into competitive, independent and collaborative investigators. A detailed plan for their research career development has been formulated, expectations and goals for achieving extramural support is outlined, the extent of departmental and university support provided to these junior faculty is substantial, clear and tangible evidence of institutional commitment has been documented, and sufficient and adequate space and equipment resources for the conduct of the proposed studies exists.