ROLE OF GHRELIN AND PYY IN POSTPARTUM BODY WEIGHT REGULATION

GHRELIN 和 PYY 在产后体重调节中的作用

• 批准号: 8359734
• 负责人: ENNETTE LARSON-MEYER
• 金额: $ 15.06万
• 依托单位: UNIVERSITY OF WYOMING
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8359734
• 关键词: Appetite Regulation; Biomedical Research; Birth; Blood; Body Composition; Body Weight; Body fat; Breast Feeding; Child; Childbirth; Desire for food; Development; Enrollment; Fasting; Funding; Grant; Hormones; Human Milk; Infant; Measurement; Metabolism; National Center for Research Resources; Obesity; Overweight; Postpartum Period; Principal Investigator; Regulation; Research; Research Infrastructure; Resources; Rest; Risk; Role; Sampling; Source; United States National Institutes of Health; Woman; Wyoming; child bearing; cost; ghrelin; polypeptide; pregnant; response; volunteer

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Large scale studies have suggested that childbearing is an important contributor to the development of obesity in many women, and that breastfeeding may be protective against risk of overweight or obesity in the mom and in the infant. It is possible that ghrelin and polypeptide YY (PYY), two recently discovered gut hormones involved in appetite regulation, are altered after child birth and with breastfeeding and are associated with body weight/body fat retention (or loss) after childbirth. It is also plausible that ghrelin and PYY are present in human milk where they may regulate appetite in the breastfed infant. The specific aims of this project are to: 1) determine whether fasting or meal-induced blood levels of these appetite regulating hormones differ between breastfeeding, non-breastfeeding and non-pregnant controls; 2) assess whether these hormones are involved in body weight regulation after childbirth; and 3) determine whether breast milk contains these two hormones. The study will enroll 15-20 breastfeeding women and 15-20 non-breastfeeding women four weeks after delivery; and 15-20 -never pregnant controls. Volunteers will have measurements of their body weight, body composition and resting metabolism, as well as their ghrelin and PYY responses to a standardized breakfast meal. Volunteers' body weight and body composition will be followed for 1 year after delivery. The breastfeeding women will also provide samples of breast milk for analysis.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 大规模研究表明，生育是许多女性肥胖的一个重要因素，母乳喂养可能可以预防母亲和婴儿超重或肥胖的风险。生长素释放肽和多肽 YY (PYY) 这两种最近发现的参与食欲调节的肠道激素可能在分娩后和母乳喂养后发生改变，并且与分娩后体重/体脂保留（或减少）有关。人乳中也可能存在生长素释放肽和 PYY，它们可以调节母乳喂养婴儿的食欲。该项目的具体目标是：1）确定母乳喂养、非母乳喂养和非怀孕对照之间这些食欲调节激素的空腹或进餐引起的血液水平是否存在差异； 2）评估这些激素是否参与产后体重调节； 3) 确定母乳中是否含有这两种激素。该研究将在产后 4 周内招募 15-20 名母乳喂养妇女和 15-20 名非母乳喂养妇女；和 15-20 从未怀孕的对照。志愿者将测量他们的体重、身体成分和静息代谢，以及他们对标准化早餐的胃饥饿素和 PYY 反应。志愿者的体重和身体成分将在分娩后一年内被跟踪。母乳喂养的妇女还将提供母乳样本进行分析。