ROLE OF GHRELIN AND PYY IN POSTPARTUM BODY WEIGHT REGULATION

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。所列机构为 中心，不一定是研究者的机构。 大规模的研究表明，生育是许多女性肥胖症发展的重要因素，母乳喂养可能会防止母亲和婴儿超重或肥胖的风险。生长激素释放肽和多肽YY（PYY），两种最近发现的参与食欲调节的肠道激素，可能在孩子出生后和母乳喂养后发生变化，并与分娩后的体重/体脂保留（或损失）有关。生长激素释放肽和PYY存在于母乳中，它们可以调节母乳喂养婴儿的食欲，这也是合理的。该项目的具体目标是：1）确定母乳喂养、非母乳喂养和非妊娠对照组之间空腹或进餐引起的这些食欲调节激素的血液水平是否不同; 2）评估这些激素是否参与分娩后的体重调节; 3）确定母乳是否含有这两种激素。该研究将招募15-20名哺乳期妇女和15-20名分娩后四周的非哺乳期妇女;以及15-20名从未怀孕的对照组。志愿者将测量他们的体重，身体成分和静息代谢，以及他们对标准化早餐的ghrelin和PYY反应。志愿者的体重和身体成分将在分娩后随访1年。哺乳妇女还将提供母乳样本进行分析。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Large scale studies have suggested that childbearing is an important contributor to the development of obesity in many women, and that breastfeeding may be protective against risk of overweight or obesity in the mom and in the infant. It is possible that ghrelin and polypeptide YY (PYY), two recently discovered gut hormones involved in appetite regulation, are altered after child birth and with breastfeeding and are associated with body weight/body fat retention (or loss) after childbirth. It is also plausible that ghrelin and PYY are present in human milk where they may regulate appetite in the breastfed infant. The specific aims of this project are to: 1) determine whether fasting or meal-induced blood levels of these appetite regulating hormones differ between breastfeeding, non-breastfeeding and non-pregnant controls; 2) assess whether these hormones are involved in body weight regulation after childbirth; and 3) determine whether breast milk contains these two hormones. The study will enroll 15-20 breastfeeding women and 15-20 non-breastfeeding women four weeks after delivery; and 15-20 -never pregnant controls. Volunteers will have measurements of their body weight, body composition and resting metabolism, as well as their ghrelin and PYY responses to a standardized breakfast meal. Volunteers' body weight and body composition will be followed for 1 year after delivery. The breastfeeding women will also provide samples of breast milk for analysis.