PI3K, AKT AND ERR-ALPHA PATHWAYS IN FLAVONOID-INHIBITING TUMORIGENESIS

类黄酮抑制肿瘤发生中的 PI3K、AKT 和 ERR-α 通路

• 批准号: 8360187
• 负责人: ALLAN Y CHEN
• 金额: $ 14.43万
• 依托单位: MARSHALL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8360187
• 关键词: Antioxidants; Apigenin; Biomedical Research; Cell Proliferation; Colon; Flavonoids; Funding; Grant; Lung; Malignant neoplasm of ovary; Malignant neoplasm of prostate; Malignant neoplasm of urinary bladder; Mediating; Molecular; National Center for Research Resources; PIK3CG gene; Pathway interactions; Principal Investigator; Proto-Oncogene Proteins c-akt; Research; Research Infrastructure; Resources; Role; Signal Pathway; Source; United States National Institutes of Health; West Virginia; angiogenesis; cancer cell; cost; fruits and vegetables; insight; malignant breast neoplasm; malignant stomach neoplasm; ovarian neoplasm; protective effect; tumor growth; tumorigenesis

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. It is known that antioxidants from fruits and vegetables have protective effects against lung, colon, breast, prostate, bladder, and stomach cancer. In this study, we will investigate the roles of potential signaling pathways inhibited by apigenin and flavonoids in mediating ovarian cancer cell proliferation and tumor growth. The study will provide further insight into the molecular mechanism(s) underlying apigenin-mediated inhibition of ovarian tumor formation and angiogenesis.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 子项目的主要研究者可能是由其他来源提供的， 包括其他NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 众所周知，水果和蔬菜中的抗氧化剂对肺癌、结肠癌、乳腺癌、前列腺癌、膀胱癌和胃癌有保护作用。在这项研究中，我们将探讨芹菜素和黄酮类化合物抑制的潜在信号通路在介导卵巢癌细胞增殖和肿瘤生长中的作用。这项研究将提供进一步深入了解芹菜素介导的抑制卵巢肿瘤形成和血管生成的分子机制。