SIGNALING PATHWAYS IN APIGENIN-INHIBITING TUMOR GROWTH

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 众所周知，水果和蔬菜中的抗氧化剂对肺癌、结肠癌、乳腺癌、前列腺癌、膀胱癌和胃癌有保护作用。在这项研究中，我们将探讨芹菜素和黄酮类化合物抑制的潜在信号通路在介导卵巢癌细胞增殖和肿瘤生长中的作用。这项研究将提供进一步深入了解芹菜素介导的抑制卵巢肿瘤形成和血管生成的分子机制。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. It is known that antioxidants from fruits and vegetables have protective effects against lung, colon, breast, prostate, bladder, and stomach cancer. In this study, we will investigate the roles of potential signaling pathways inhibited by apigenin and flavonoids in mediating ovarian cancer cell proliferation and tumor growth. The study will provide further insight into the molecular mechanism(s) underlying apigenin-mediated inhibition of ovarian tumor formation and angiogenesis.