SIGNALING PATHWAYS IN APIGENIN-INHIBITING TUMOR GROWTH

芹菜素抑制肿瘤生长的信号通路

• 批准号: 7960304
• 负责人: ALLAN Y CHEN
• 金额: $ 16.69万
• 依托单位: MARSHALL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-20 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7960304
• 关键词: Antioxidants; Apigenin; Biomedical Research; Bladder; Breast; Cell Proliferation; Colon; Computer Retrieval of Information on Scientific Projects Database; Flavonoids; Funding; Grant; Institution; Lung; Malignant neoplasm of ovary; Mediating; Molecular; Prostate; Research; Research Personnel; Resources; Role; Signal Pathway; Source; United States National Institutes of Health; West Virginia; angiogenesis; cancer cell; fruits and vegetables; insight; malignant stomach neoplasm; ovarian neoplasm; protective effect; tumor growth

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. It is known that antioxidants from fruits and vegetables have protective effects against lung, colon, breast, prostate, bladder, and stomach cancer. In this study, we will investigate the roles of potential signaling pathways inhibited by apigenin and flavonoids in mediating ovarian cancer cell proliferation and tumor growth. The study will provide further insight into the molecular mechanism(s) underlying apigenin-mediated inhibition of ovarian tumor formation and angiogenesis.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 众所周知，水果和蔬菜中的抗氧化剂对肺癌、结肠癌、乳腺癌、前列腺癌、膀胱癌和胃癌具有保护作用。在本研究中，我们将研究芹菜素和黄酮类化合物抑制的潜在信号通路在介导卵巢癌细胞增殖和肿瘤生长中的作用。该研究将进一步深入了解芹菜素介导的卵巢肿瘤形成和血管生成抑制的分子机制。