EVALUATING THE EFFECTS OF EXOGENOUS PERTURBATION OF PLATELET LIPID COMPOSITION

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 血小板是通过形成凝块、分泌化学物质和提供响应于血管损伤的反应性表面来维持正常血液流动和分布的关键细胞组分。 构成细胞外基质的蛋白质可以刺激这些血小板功能，并且还在刺激骨髓中新血小板的产生中发挥作用。 我的实验室正在研究血小板及其祖细胞在接触基质时的反应。 我们的目的是阐明一些细胞外和细胞内的信号，影响现有的血小板的活性和新的血小板的形成。 具体来说，我的实验室有两个主要项目。 首先是确定什么信号促进血小板前体细胞（称为巨核细胞）形成新的血小板，这是与布里格姆妇女医院的Joe Italiano博士合作的一个项目。 第二个是了解饮食中的omega-3脂肪酸如何影响血小板功能，这是一个与桑福德研究所的Bill Harris博士合作的项目。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Platelets are a critical cellular component for maintaining normal blood flow and distribution by forming clots, secreting chemicals, and providing a reactive surface in response to blood vessel damage. Proteins that compose extracellular matrices can stimulate these platelet functions, and also play a role in stimulating the production of new platelets in the bone marrow. My lab is investigating how platelets and their progenitors respond when coming into contact with matrices. We aim to elucidate some of the extracellular and intracellular signals that influence the activity of existing blood platelets and the formation of new platelets. Specifically, my lab has two main projects. The first is to determine what signals promote the formation of new platelets from platelet precursor cells called megakaryocytes, a project in collaboration with Dr. Joe Italiano of the Brigham and Women's Hospital. The second is to understand how dietary omega-3 fatty acids affect platelet function, a project that is run in collaboration with Dr. Bill Harris at Sanford Research.