ELUCIDATING SIGNALS IN EXISTING AND NEW PLATELETS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 血小板是维持正常血流和分布的关键细胞成分，它形成血栓，分泌化学物质，并提供反应血管损伤的反应性表面。构成细胞外基质的蛋白质可以刺激这些血小板功能，也可以在刺激骨髓中产生新的血小板方面发挥作用。我的实验室正在研究血小板及其祖细胞在接触基质时的反应。我们的目标是阐明一些细胞外和细胞内的信号，这些信号影响现有的血小板的活性和新的血小板的形成。具体地说，我的实验室有两个主要项目。第一个是确定是什么信号促进了被称为巨核细胞的血小板前体细胞形成新的血小板，这是一个与布里格姆妇女医院的乔·意大利亚诺博士合作的项目。第二个是了解饮食中的omega-3脂肪酸如何影响血小板功能，这是一个与桑福德研究中心的比尔·哈里斯博士合作开展的项目。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Platelets are a critical cellular component for maintaining normal blood flow and distribution by forming clots, secreting chemicals, and providing a reactive surface in response to blood vessel damage. Proteins that compose extracellular matrices can stimulate these platelet functions, and also play a role in stimulating the production of new platelets in the bone marrow. My lab is investigating how platelets and their progenitors respond when coming into contact with matrices. We aim to elucidate some of the extracellular and intracellular signals that influence the activity of existing blood platelets and the formation of new platelets. Specifically, my lab has two main projects. The first is to determine what signals promote the formation of new platelets from platelet precursor cells called megakaryocytes, a project in collaboration with Dr. Joe Italiano of the Brigham and Women's Hospital. The second is to understand how dietary omega-3 fatty acids affect platelet function, a project that is run in collaboration with Dr. Bill Harris at Sanford Research.