INHIBITION OF ANTIBIOTIC-INDUCED MUTATION IN BACTERIA

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 子项目的主要研究者可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 细菌对抗菌药物的耐药性有可能成为全球健康危机。这一问题需要大量的研究来发现新的药物靶点以及合成抗生素。虽然这种策略对于保持抗生素耐药性生物体的进化至关重要，但对抗耐药性过程也很重要。细菌可以通过染色体突变获得对抗生素的抗性，并且赋予抗性的染色体突变的高比率至少部分是由于诱导修复由抗生素直接或间接引起的受损DNA的途径。与目前正在研究的其他抗菌肽不同，我们正在寻找减少细菌突变性而不是杀死细菌的肽。一旦鉴定出来，这些肽就有可能作为抗生素添加剂，并可用于降低细菌的进化速度，无论药物的分子靶点如何。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Bacterial resistance to antimicrobial drugs has the potential to become a global health crisis. This problem has necessitated an explosion of research to discover new drug targets as well as synthetic antibiotics. While this tactic is essential to stay ahead of the evolution of antibiotic resistant organisms, it is also important to combat the resistance process. Bacteria can acquire resistance to antibiotics through chromosomal mutations and high rates of resistance-conferring chromosomal mutations are at least partially due to pathways induced to repair damaged DNA caused either directly or indirectly by the antibiotic. Unlike other antimicrobial peptides currently being studied, we are looking for peptides that reduce the mutability of bacteria as opposed to killing the bacteria. Once identified, these peptides could potentially serve as antibiotic additives and could be used to reduce the evolution rate of bacteria regardless of the molecular target of the drug.