INHIBITION OF ANTIBIOTIC-INDUCED MUTATION IN BACTERIA

抑制抗生素诱导的细菌突变

• 批准号: 8167586
• 负责人: SHELLEY LUSETTI
• 金额: $ 10.85万
• 依托单位: NEW MEXICO STATE UNIVERSITY LAS CRUCES
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-01 至 2011-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8167586
• 关键词: Antibiotic Resistance; Antibiotic-resistant organism; Antibiotics; Antimicrobial Resistance; Bacteria; Computer Retrieval of Information on Scientific Projects Database; DNA Repair; Drug Delivery Systems; Evolution; Explosion; Funding; Grant; Induced Mutation; Institution; Molecular Target; Mutation; Pathway interactions; Peptides; Pharmaceutical Preparations; Research; Research Personnel; Resistance; Resistance Process; Resources; Source; United States National Institutes of Health; antimicrobial drug; antimicrobial peptide; combat; global health; killings

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Bacterial resistance to antimicrobial drugs has the potential to become a global health crisis. This problem has necessitated an explosion of research to discover new drug targets as well as synthetic antibiotics. While this tactic is essential to stay ahead of the evolution of antibiotic resistant organisms, it is also important to combat the resistance process. Bacteria can acquire resistance to antibiotics through chromosomal mutations and high rates of resistance-conferring chromosomal mutations are at least partially due to pathways induced to repair damaged DNA caused either directly or indirectly by the antibiotic. Unlike other antimicrobial peptides currently being studied, we are looking for peptides that reduce the mutability of bacteria as opposed to killing the bacteria. Once identified, these peptides could potentially serve as antibiotic additives and could be used to reduce the evolution rate of bacteria regardless of the molecular target of the drug.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 细菌对抗菌药物的耐药性有可能成为全球健康危机。这个问题需要大量的研究来发现新的药物靶点以及合成抗生素。虽然这种策略对于保持领先于抗生素抗性生物体的进化至关重要，但对抗耐药性过程也很重要。细菌可以通过染色体突变获得对抗生素的耐药性，而产生耐药性的染色体突变率高至少部分是由于修复由抗生素直接或间接引起的受损 DNA 所诱导的途径。与目前正在研究的其他抗菌肽不同，我们正在寻找能够减少细菌突变性而不是杀死细菌的肽。一旦鉴定出来，这些肽有可能作为抗生素添加剂，并可用于降低细菌的进化速度，无论药物的分子靶点如何。