GAS INJECTION USING A SPECIAL CATHETER FOR LUNG PERFUSION IMAGING IN THE RAT
使用特殊导管进行气体注射进行大鼠肺灌注成像
基本信息
- 批准号:8363156
- 负责人:
- 金额:$ 1.84万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2011
- 资助国家:美国
- 起止时间:2011-07-01 至 2012-06-30
- 项目状态:已结题
- 来源:
- 关键词:CathetersChemicalsDimensionsFiberFundingGasesGrantImageInjection of therapeutic agentLiquid substanceLungMapsMedicalMembraneMicroscopyNational Center for Research ResourcesPerfusionPhasePolymersPorosityPrincipal InvestigatorProductionPropertyPulmonary EmbolismPulmonary Gas ExchangeRattusResearchResearch InfrastructureResistanceResolutionResourcesSalineSliceSourceSpectrum AnalysisStructure of jugular veinTailThickUnited States National Institutes of HealthVeinsVenousWateraqueousbasecontrolled releasecostimaging modalitylung imagingnovelpressureresearch studysubmicrontheories
项目摘要
This subproject is one of many research subprojects utilizing the resources
provided by a Center grant funded by NIH/NCRR. Primary support for the subproject
and the subproject's principal investigator may have been provided by other sources,
including other NIH sources. The Total Cost listed for the subproject likely
represents the estimated amount of Center infrastructure utilized by the subproject,
not direct funding provided by the NCRR grant to the subproject or subproject staff.
Recently, a novel imaging method for imaging lung perfusion and pulmonary gas exchange has been developed at CIVM. It is based on venous injection (tail vein or jugular vein) of hyperpolarized (HP) 129Xe dissolved in saline. 129Xe is cleared through the lungs where it can be imaged with relatively high resolution. In addition to mapping perfusion, quantitative information may be obtained from repetitive imaging or spectroscopy and adaptation of the Kety-Schmidt theory.
The new project aims at avoiding injection of larger quantities of fluid by replacing injections of HP 129Xe dissolved in saline with direct gas injections. To avoid creation of pulmonary embolism due to production of gas bubbles during the injections, a novel type of catheter will be used. The catheter contains a microporous hollow-fiber membrane (a thin-walled, opaque, polymer membrane that is used in a variety of medical, controlled-release, or biotechnological applications). It features submicron porosity, relatively high burst strengths, and excellent chemical resistance. Due to their hydrophobic properties and small pore size, the membrane resists water permeation, except at high pressures. The project will be divided into three phases: (1) verification of the bubble-free 129Xe injection into aqueous fluids in a phantom experiment; (2) replication of previous results obtained with saline injections by using membrane-facilitated direct gas injections in 10 rats; (3) high-resolution perfusion imaging (in-plane submillimeter voxel dimensions, slice thickness 5mm or less) in 10 rats.
这个子项目是利用这些资源的众多研究子项目之一
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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HARALD MOLLER其他文献
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{{ truncateString('HARALD MOLLER', 18)}}的其他基金
APPLICATION OF HYPERPOLARIZED XENON-129 VIA THE VASCULAR SYSTEM
通过血管系统应用超极化 XENON-129
- 批准号:
8363153 - 财政年份:2011
- 资助金额:
$ 1.84万 - 项目类别:
APPLICATION OF HYPERPOLARIZED XENON-129 VIA THE VASCULAR SYSTEM
通过血管系统应用超极化 XENON-129
- 批准号:
8171568 - 财政年份:2010
- 资助金额:
$ 1.84万 - 项目类别:
GAS INJECTION USING A SPECIAL CATHETER FOR LUNG PERFUSION IMAGING IN THE RAT
使用特殊导管进行气体注射进行大鼠肺灌注成像
- 批准号:
8171573 - 财政年份:2010
- 资助金额:
$ 1.84万 - 项目类别:
GAS INJECTION USING A SPECIAL CATHETER FOR LUNG PERFUSION IMAGING IN THE RAT
使用特殊导管进行气体注射进行大鼠肺灌注成像
- 批准号:
7956902 - 财政年份:2009
- 资助金额:
$ 1.84万 - 项目类别:
APPLICATION OF HYPERPOLARIZED XENON-129 VIA THE VASCULAR SYSTEM
通过血管系统应用超极化 XENON-129
- 批准号:
7956893 - 财政年份:2009
- 资助金额:
$ 1.84万 - 项目类别:
APPLICATION OF HYPERPOLARIZED XENON-129 VIA THE VASCULAR SYSTEM
通过血管系统应用超极化 XENON-129
- 批准号:
7726171 - 财政年份:2008
- 资助金额:
$ 1.84万 - 项目类别:
APPLICATION OF HYPERPOLARIZED XENON-129 VIA THE VASCULAR SYSTEM
通过血管系统应用超极化 XENON-129
- 批准号:
7601222 - 财政年份:2007
- 资助金额:
$ 1.84万 - 项目类别:
APPLICATION OF HYPERPOLARIZED XENON-129 VIA THE VASCULAR SYSTEM
通过血管系统应用超极化 XENON-129
- 批准号:
7358308 - 财政年份:2006
- 资助金额:
$ 1.84万 - 项目类别:
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