ULTRASTRUCTURE OF THALAMIC INPUTS TO CORTICAL INTERNEURONS

丘脑输入皮质中间神经元的超微结构

• 批准号: 8361943
• 负责人: MASSIMO SCANZIANI
• 金额: $ 2.47万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8361943
• 关键词: Dyes; Electrons; Funding; Glutamates; Grant; Image Analysis; Interneurons; Joints; Label; Light; Microscopic; National Center for Research Resources; Principal Investigator; Research; Research Infrastructure; Resources; Source; Synapses; Thalamic structure; United States National Institutes of Health; cost; inhibitory neuron; postsynaptic

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Activity in the thalamus triggers widespread cortical inhibition. This is not because thalamic neurons are inhibitory (they release the excitatory transmitter glutamate) but because they form powerful synapses with inhibitory interneurons in Layer IV of the cortex. We will examine the ultrastructure of these unusually strong connections in a joint light/electron microscopic study using dye labeling of both the thalamic inputs and their postsynaptic interneuron targets.

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 丘脑的活动会引发广泛的皮质抑制。这不是因为丘脑神经元是抑制性的(它们释放兴奋性递质谷氨酸)，而是因为它们与大脑皮层第四层的抑制性中间神经元形成了强大的突触。我们将在一项联合的光/电子显微镜研究中，使用丘脑输入及其突触后神经元间靶标的染料标记来检查这些异常强大的联系的超微结构。