LIPOSOME WITH NANO GOLD PARTICLES

纳米金颗粒脂质体

• 批准号: 8361118
• 负责人: King Li
• 金额: $ 1.23万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8361118
• 关键词: Biodistribution; Body Temperature; Drug Carriers; Drug Kinetics; Drug Packaging; Electron Microscopy; Funding; Gold; Grant; Heating; Image; Lasers; Lipids; Liposomes; National Center for Research Resources; Pharmaceutical Preparations; Physiological; Principal Investigator; Relative (related person); Research; Research Infrastructure; Resources; Source; Surface; Techniques; Temperature; Tissues; United States National Institutes of Health; aqueous; base; clinical application; cost; improved; macromolecule; nanoGold; nanoparticle; particle

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Liposomal drug carriers have been used to package drugs in order to alter their biodistribution and pharmacokinetics, but their clinical application are limited by slow release. Liposomes have also been developed for active deployment based on heating via global (relative to the size of the liposome) tissue heating. While it appears that these techniques can improve the localization of the drug, the lingering problem of liposome instability at body temperature remains. Fully polymerized drug carriers have also been used for similar purposes to carry imaging agents, while they tend to have the opposite problem, that is, they are not easily opened at any temperature achievable in an aqueous medium. In this study, we mixed polymerizable lipid with unpolymerizable lipid to yield a partially polymerized liposomes (PPLs) and gold nanoparticles were attached on the surface of the PPLs through Au-SH-lipid linkage. By optimizing the ratio of the two types of lipids, we prepared gold particle attached PPLs which were stable at physiological condition, and could be opened by laser activation to release drug.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 子项目的主要研究者可能是由其他来源提供的， 包括其他NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 脂质体药物载体用于药物的包装以改变药物的生物分布和药代动力学，但其缓慢释放限制了其临床应用。脂质体 也已经被开发用于基于通过整体（相对于脂质体的尺寸）组织加热的加热的主动部署。虽然这些技术似乎可以改善 尽管药物的局部化，但是脂质体在体温下不稳定的挥之不去的问题仍然存在。完全聚合的药物载体也已用于类似的目的， 试剂，而它们往往具有相反的问题，即它们在水性介质中可达到的任何温度下都不容易打开。在这项研究中，我们混合了可聚合的 脂质与不可聚合的脂质进行聚合以产生部分聚合的脂质体（PPL），并且金纳米颗粒通过Au-SH-脂质键连接在PPL的表面上。通过优化 通过改变两种脂质的比例，制备出了在生理条件下稳定的金颗粒修饰的PPL，并能被激光激活打开释放药物。