STREPTAVIDIN-CONTAINING COMPLEXES

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。次级项目的主要支助 子项目的主要研究者可能是由其他来源提供的， 包括其它NIH来源。 为子项目列出的总成本可能 代表子项目使用的中心基础设施的估计数量， NCRR赠款不直接向子项目或子项目工作人员提供资金。 长期目标是设计可通过设计组装的纳米级结构的大分子组件。这里研究的分子复合物代表了一种将含有链霉亲和素的支柱连接到各种对称性的节点分子的方法。我们建议使用cryo-EM来提供工程纳米结构的结构测定。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The long-term objective is to engineer macromolecular components for nanoscale structures that can be assembled by design. The molecular complex under investigation here represents a way to link streptavidin-containing struts to node molecules of various symmetries. We propose to use cryo-EM to provide a structural assay of the engineered nano-structures.