HIV-HOST PROTEIN COMPLEXES

HIV 宿主蛋白复合物

• 批准号: 8363625
• 负责人: ALAN D FRANKEL
• 金额: $ 2.02万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8363625
• 关键词: Complex; Computer Graphics; Funding; Grant; HIV; Imagery; Informatics; Laboratories; National Center for Research Resources; Principal Investigator; Proteins; Proteomics; RNA; RNA-Binding Proteins; Research; Research Infrastructure; Resources; Source; Structure; Transcription Coactivator; United States National Institutes of Health; Work; biocomputing; cost; tool

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. We have been conducting proteomic studies to identify host proteins that interact with HIV proteins in order to determine the structures of relevant complexes. Our structural studies focus primarily on complexes with the Tat transcription activator and Rev RNA export factor, both RNA-binding proteins. Graphical analyses of the structures utilizing Computer Graphics Laboratory tools are instrumental for this work.

这个子项目是利用这些资源的众多研究子项目之一