HIV-HOST PROTEIN COMPLEXES

HIV 宿主蛋白复合物

• 批准号: 8170565
• 负责人: ALAN D FRANKEL
• 金额: $ 0.72万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8170565
• 关键词: Complex; Computer Graphics; Computer Retrieval of Information on Scientific Projects Database; Funding; Grant; HIV; Institution; Laboratories; Proteins; Proteomics; RNA; RNA-Binding Proteins; Research; Research Personnel; Resources; Source; Structure; Transcription Coactivator; United States National Institutes of Health; Work; protein complex; tool

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We have been conducting proteomic studies to identify host proteins that interact with HIV proteins in order to determine the structures of relevant complexes. Our structural studies focus primarily on complexes with the Tat transcription activator and Rev RNA export factor, both RNA-binding proteins. Graphical analyses of the structures utilizing Computer Graphics Laboratory tools are instrumental for this work.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 我们一直在进行蛋白质组学研究，以确定与 HIV 蛋白相互作用的宿主蛋白，从而确定相关复合物的结构。 我们的结构研究主要集中于 Tat 转录激活因子和 Rev RNA 输出因子（这两种 RNA 结合蛋白）的复合物。 利用计算机图形实验室工具对结构进行图形分析对于这项工作很有帮助。