HIV-HOST PROTEIN COMPLEXES

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 研究中心，而研究中心不一定是研究者所在的机构。 我们一直在进行蛋白质组学研究，以确定与HIV蛋白相互作用的宿主蛋白质，以确定相关复合物的结构。 我们的结构研究主要集中在复合物与达特转录激活因子和Rev RNA输出因子，RNA结合蛋白。 利用计算机图形实验室工具的结构图形分析是这项工作的工具。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We have been conducting proteomic studies to identify host proteins that interact with HIV proteins in order to determine the structures of relevant complexes. Our structural studies focus primarily on complexes with the Tat transcription activator and Rev RNA export factor, both RNA-binding proteins. Graphical analyses of the structures utilizing Computer Graphics Laboratory tools are instrumental for this work.