QUANTITATIVE AND QUALITITATIVE FLUORESCENCE MODULATED IMAGING AND TOMOGRAPHY

定量和定性荧光调制成像和断层扫描

• 批准号: 8362634
• 负责人: ANTHONY J DURKIN
• 金额: $ 3.89万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8362634
• 关键词: Algorithms; Biotechnology; Fluorescence; Funding; Grant; Image; Lasers; Measurement; Measures; Metric; National Center for Research Resources; Principal Investigator; Research; Research Infrastructure; Resources; Source; United States National Institutes of Health; cost; fluorophore; quantum; reconstruction; tomography

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The purpose of this study is to demonstrate Fluorescent modulated imaging (fMI) via the quantitative and qualitative measurement of fluorophore phantoms. Fluorescent perturbations with various spatial and depth profiles in phantoms will be investigated. Qualititatively, the ability for spatial localization of the fluorophore. Quantitatively, the ability to measure fluorophore concentration as well as concentration and pH independent fluorophore metrics such as quantum yield will be investigated. Finally, tomographic reconstruction algorithms will be developed in parallel.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 本研究的目的是通过对荧光体的定量和定性测量来证明荧光调制成像（fMI）。将研究幻影中具有各种空间和深度分布的荧光扰动。 荧光团的空间定位能力。 定量，测量荧光团浓度以及浓度和pH独立的荧光团度量，如量子产率的能力将被调查。 最后，层析重建算法将并行开发。