OPTICAL BIOPSY OF HUMAN SKIN IN CONJUCTION WITH LASER TREATMENT

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 本研究的目的是量化治疗前后皮肤和邻近正常皮肤（体内）的光学特性和发色团浓度。 此外，在某些情况下，我们将重复进行测量，以记录治疗后皮肤和邻近正常皮肤在几周内的变化。最终，我们有兴趣详细了解皮肤对治疗的反应，以优化治疗。此外，我们将比较SS-FDPM获得的结果与使用调制成像获得的结果，以客观地评估每种技术的优点和缺点。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The objective of this study is to quantify optical properties and chromophore concentrations for pre and post treatment skin and adjacent normal skin (in-vivo). Furthermore, in select cases, we will repeatedly perform measurements to record changes in post treatment skin and adjacent normal skin over a period of several weeks. Ultimately we are interested in developing a detailed understanding of the response of skin to therapy with the objective of optimizing therapy. Furthermore we will compare results obtained with SS-FDPM to those arrived at using Modulated Imaging in order to objectively assess the strengths and weaknesses of each technique.