A MOLECULAR FOUNDATION FOR THE TREATMENT OF ARSENIC POISONING IN BANGLADESH

孟加拉国治疗砷中毒的分子基础

• 批准号: 8362084
• 负责人: Graham Neil George
• 金额: $ 0.52万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-03-01 至 2012-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8362084
• 关键词: Affect; Area; Arsenic; Arsenic Poisoning; Bangladesh; Chronic; Foundations; Funding; Grant; Molecular; National Center for Research Resources; Poisoning; Principal Investigator; Radiation; Research; Research Infrastructure; Resources; Roentgen Rays; Source; Spectrum Analysis; Toxic effect; United States National Institutes of Health; Work; absorption; cost; selenium deficiency; structural biology

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. In what has been called the world?s worst mass poisoning, between 35 and 70 million people are affected by chronic low-level arsenic poisoning in Bangladesh and surrounding areas. We have previously suggested that this poisoning is not directly due to the toxic effects of arsenic, but is instead primarily due to arsenic-induced selenium deficiency. We plan to build on our earlier work to provide a molecular foundation for the treatment of chronic low-level arsenic poisoning in Bangladesh and other affected areas. X-ray absorption spectroscopy (XAS) holds the key to these discoveries.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 在所谓的世界里？在孟加拉国及其周边地区，有3500万至7000万人受到慢性低水平砷中毒的影响。我们以前曾提出，这种中毒不是直接由于砷的毒性作用，而是主要由于砷引起的硒缺乏。我们计划在先前工作的基础上，为治疗孟加拉国和其他受影响地区的慢性低水平砷中毒提供分子基础。X射线吸收光谱（XAS）是这些发现的关键。