PHYTOSTEROL GLYCOSIDES REDUCE CHOLESTEROL ABSORPTION IN HUMANS

植物甾醇糖苷减少人体胆固醇吸收

• 批准号: 8361408
• 负责人: XI LIN
• 金额: $ 0.85万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8361408
• 关键词: Biological; Cholesterol; Equilibrium; Excretory function; Food; Funding; Glycosides; Grant; Human; Intestines; Mass Spectrum Analysis; National Center for Research Resources; Phytosterols; Principal Investigator; Research; Research Infrastructure; Resources; Source; Testing; United States National Institutes of Health; biomedical resource; cholesterol absorption; cost

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Dietary phytosterols inhibit intestinal cholesterol absorption and regulate whole body cholesterol excretion and balance. However, they are biochemically heterogeneous and a portion is glycosylated in some foods with unknown effects on biological activity. We tested the hypothesis that phytosterol glycosides reduce cholesterol absorption in humans.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 膳食植物甾醇抑制肠道胆固醇吸收，调节全身胆固醇排泄和平衡。然而，它们在生物化学上是异质的，并且在某些食物中有一部分被糖基化，对生物活性的影响未知。我们测试了植物甾醇糖苷减少人体胆固醇吸收的假设。