SYNTHESIS OF NEW ORGANIC MOLECULES TO ADDRESS IMPORTANT METAL-MEDIATED PROCESSES

合成新的有机分子以解决重要的金属介导的过程

基本信息

  • 批准号:
    8361424
  • 负责人:
  • 金额:
    $ 2.81万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2011
  • 资助国家:
    美国
  • 起止时间:
    2011-01-01 至 2011-12-31
  • 项目状态:
    已结题

项目摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Our research program uses inorganic chemistry, organic chemistry, and biological chemistry to address important metal-mediated processes with energy, biological, and medical relevance. An interdisciplinary, problem-based approach will be employed to synthesize and characterize new organic molecules and inorganic complexes, with the ultimate goal to tackle unsolved problems with broad implications to our society. Three main research areas will be pursued, which are expected to attract students and postdocs with different research interests and to provide them with a broad knowledge base applicable in most chemistry careers. Non-Heme Iron Enzymes. Non-heme iron enzymes catalyze a wide range of oxidation and oxygenation reactions. This project aims to design and synthesize specific inhibitors of O2-activating non-heme iron enzymes by taking advantage of the enzyme's substrate specificity. Renewable Energy Catalysis. The global energy consumption is expected to at least double in the next fifty years due to population and economic growth. In this context, there is a large interest in developing molecular systems that can capture solar energy and used it to produce oxygen and hydrogen from water. This project regards the design, synthesis, and characterization of polymetallic complexes as potential catalysts for water oxidation. Amyloid b Peptides in Alzheimer's Disease. Alzheimer's Disease (AD) is the most common neurodegenerative disease. The brains of patients with AD are characterized by the deposition of amyloid b (Ab) peptide plaques, which accumulate unusually high concentrations of copper, iron, and zinc. This project is directed toward the investigation of the interaction of transition metal ions with Ab peptides and the study of the role of metal ions in amyloid plaque and reactive oxygen species (ROS) formation
这个子项目是利用这些资源的众多研究子项目之一

项目成果

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LIVIU M. MIRICA其他文献

LIVIU M. MIRICA的其他文献

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{{ truncateString('LIVIU M. MIRICA', 18)}}的其他基金

Blood-Brain Barrier Permeable Multimodal Imaging Agents for Neurodegenerative Diseases
用于神经退行性疾病的血脑屏障渗透性多模态成像剂
  • 批准号:
    10740351
  • 财政年份:
    2023
  • 资助金额:
    $ 2.81万
  • 项目类别:
NOVEL BIFUNCTIONAL CHEMICAL AGENTS AS THERANOSTIC TOOLS FOR AMYLOID DISEASES
新型双功能化学制剂作为淀粉样蛋白疾病的治疗工具
  • 批准号:
    9277494
  • 财政年份:
    2015
  • 资助金额:
    $ 2.81万
  • 项目类别:
SYNTHESIS OF NEW ORGANIC MOLECULES TO ADDRESS IMPORTANT METAL-MEDIATED PROCESSES
合成新的有机分子以解决重要的金属介导的过程
  • 批准号:
    8168834
  • 财政年份:
    2010
  • 资助金额:
    $ 2.81万
  • 项目类别:
Studies of ascorbate-dependent, non-heme iron enzyme ACC oxidase
抗坏血酸依赖性非血红素铁酶 ACC 氧化酶的研究
  • 批准号:
    7273395
  • 财政年份:
    2007
  • 资助金额:
    $ 2.81万
  • 项目类别:
Studies of ascorbate-dependent, non-heme iron enzyme ACC oxidase
抗坏血酸依赖性非血红素铁酶 ACC 氧化酶的研究
  • 批准号:
    7371916
  • 财政年份:
    2007
  • 资助金额:
    $ 2.81万
  • 项目类别:
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