MICE DEFICIENT IN GROUP VIB PHOSPHOLIPASE A2 (IPLA2GAMMA) EXHIBIT RELATIVE

VIB 组磷脂酶 A2 (IPLA2GAMMA) 缺陷的小鼠表现出相关性

• 批准号: 8361444
• 负责人: JOHN W TURK
• 金额: $ 1.22万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8361444
• 关键词: Catalysis; Enzymes; Exhibits; Family; Funding; Glucose Intolerance; Grant; Knockout Mice; Mass Spectrum Analysis; Metabolism; Mitochondria; Morphology; Mus; National Center for Research Resources; Organelles; Phospholipase A2; Phospholipases A; Play; Principal Investigator; Relative (related person); Research; Research Infrastructure; Resources; Role; Source; Stress; United States National Institutes of Health; Wild Type Mouse; biomedical resource; cost; human PLA2G6 protein; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Phospholipases A(2) (PLA(2)) play important roles in metabolic processes, and the Group VI PLA(2) family is comprised of intracellular enzymes that do not require Ca(2+) for catalysis. Mice deficient in Group VIA PLA(2) (iPLA(2)beta) develop more severe glucose intolerance than wild-type (WT) mice in response to dietary stress. Group VIB PLA(2) (iPLA(2)gamma) is a related enzyme distributed in membranous organelles, including mitochondria, and iPLA(2)gamma knockout (KO) mice exhibit altered mitochondrial morphology and function.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其他NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 磷脂酶A（2）（PLA（2））在代谢过程中起重要作用，并且VI族PLA（2）家族由不需要Ca（2+）进行催化的细胞内酶组成。VIA组PLA（2）（iPLA（2）β）缺陷的小鼠在响应饮食应激时比野生型（WT）小鼠发展更严重的葡萄糖耐受不良。VIB族PLA（2）（iPLA（2）gamma）是一种分布在膜细胞器（包括线粒体）中的相关酶，iPLA（2）gamma敲除（KO）小鼠表现出线粒体形态和功能的改变。