Biomolecular Analysis Core D

生物分子分析核心通过执行质量来提高效率和成本效益 为CNRU调查人员提供光谱分析和某些其他分析。酷睿提供最先进的质量 测定结构和量化生物中的营养物质和有关物质的光谱分析 标本。核心提供集中化、标准化的分析程序，允许研究 与营养相关的生理和病理生理事件的分子机制。 生物分子分析核心的具体目标是： 为学生和研究员提供有关质谱学原理和使用质谱仪的培训 系统，例如，气相色谱(GC)/MS、同位素比(IR)/MS、电喷雾电离 (ESI)/串联MS和基质辅助激光解吸电离(MALDI)/飞行时间/(TOF)/ 与营养相关的生物分子分析。 开发新的MS方法来鉴定和定量涉及到的分子 营养相关的生理学和病理生理学事件。 执行与服务相关的MS分析，例如目标分析物的定量和获得光谱 用于结构鉴定。 协助CNRU研究人员开发MS分析方法。 为解释MS数据提供咨询。 开发和传播适用于营养研究的生物医学MS新方法。 提供和维护用于营养研究的功能性MS系统。 与生物分子分析核心员工合作进行营养研究。 通过提供集中的MS服务和咨询，减少与营养研究相关的成本 商业MS服务或个人仪器维护成本的一小部分 调查人员的实验室。

The Biomolecular Analysis Core increases efficiency and cost effectiveness by performing mass spectrometric and certain other analyses for CNRU investigators. The Core provides state-of-the-art mass spectrometry to determine structures and to quantify nutrients and related substances in biological specimens. The Core provides centralized, standardized analytical procedures that permit study of molecular mechanisms for nutrient-related physiologic and pathophysiologic events. Specific objectives of the Biomolecular Analysis Core are: To provide training to students and fellows in principles of mass spectrometry (MS) and use of MS systems, e.g., gas chromatography (GC)/MS, isotope ratio (IR)/MS, electrospray ionization (ESI)/tandem MS, and matrix assisted laser desorption ionization (MALDI)/time of flight/ (TOF)/MS in analysis of nutrition-related biomolecules. To develop new MS methods for structural identification and quantitation of molecules involved in nutrition-related physiologic and pathophysiologic events. To perform service-related MS analyses, e.g. quantitation of target analytes and obtaining spectra for structural identification. To assist CNRU investigators in developing MS assays. To provide consultation in interpreting MS data. To develop and disseminate new approaches in biomedical MS applicable to nutrition research. To provide and maintain functional MS systems for use in nutrition research. To perform collaborative nutrition research studies involving Biomolecular Analysis Core staff. To reduce nutrition research-related costs by providing centralized MS services and consultation at a fraction of the cost for commercial MS services or of maintaining instruments in individual investigators' laboratories.