TOWARD TOTAL STRUCTURAL ANALYSIS OF CARDIOLIPINS: MULTIPLE-STAGE LINEAR ION-TRAP

心磷脂的总结构分析：多级线性离子阱

• 批准号: 8361439
• 负责人: JOHN W TURK
• 金额: $ 4.32万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8361439
• 关键词: Cardiolipins; Fatty Acids; Funding; Glycerol; Grant; Ions; Location; Mass Spectrum Analysis; National Center for Research Resources; Principal Investigator; Research; Research Infrastructure; Resources; Source; Staging; United States National Institutes of Health; Vertebral column; biomedical resource; cost; pi bond

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. ESI multiple-stage linear ion-trap (LIT) mass spectrometric approaches for a near-complete structural characterization of cardiolipins (CLs), including identification of the fatty acyl substituents, assignment of the fatty acid substituents on the glycerol backbone, and location of the double-bond(s) or cyclopropyl group along the fatty acid chain are described.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 采用电喷雾多级线性离子阱（LIT）质谱法对心磷脂（CL）进行了近完整的结构表征，包括脂肪酰基取代基的鉴定、甘油主链上脂肪酸取代基的归属以及脂肪酸链上双键或环丙基沿着的位置。