THE EFFECTS OF PHYTOSTEROLS PRESENT IN NATURAL FOOD MATRICES ON CHOLESTEROL

天然食品基质中存在的植物甾醇对胆固醇的影响

• 批准号: 8361451
• 负责人: RICHARD E. OSTLUND
• 金额: $ 1.31万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8361451
• 关键词: Cholesterol; Cholesterol Homeostasis; Diet; Excretory function; Food; Funding; Grant; Intestines; Investigation; LDL Cholesterol Lipoproteins; Mass Fragmentography; Mass Spectrum Analysis; Metabolic; Methods; National Center for Research Resources; Nutrient; Oral Administration; Phytosterols; Plasma; Principal Investigator; Randomized; Reducing diet; Research; Research Infrastructure; Resources; Source; Testing; Tracer; United States National Institutes of Health; biomedical resource; cholesterol absorption; cost; feeding

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Background/Objectives:Extrinsic phytosterols supplemented to the diet reduce intestinal cholesterol absorption and plasma low-density lipoprotein (LDL)-cholesterol. However, little is known about their effects on cholesterol metabolism when given in native, unpurified form and in amounts achievable in the diet. The objective of this investigation was to test the hypothesis that intrinsic phytosterols present in unmodified foods alter whole-body cholesterol metabolism.Subjects/Methods:In all, 20 out of 24 subjects completed a randomized, crossover feeding trial wherein all meals were provided by a metabolic kitchen. Each subject consumed two diets for 4 weeks each. The diets differed in phytosterol content (phytosterol-poor diet, 126 mg phytosterols/2000 kcal; phytosterol-abundant diet, 449 mg phytosterols/2000 kcal), but were otherwise matched for nutrient content. Cholesterol absorption and excretion were determined by gas chromatography/mass spectrometry after oral administration of stable isotopic tracers.

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