DIETARY CONTENT & GASTROINTESTINAL ABSORPTION OF D CHIRO INOSITOL & PINITOL

膳食含量

• 批准号: 6665877
• 负责人: RICHARD E. OSTLUND
• 金额: $ 15.75万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-08-01 至 2003-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6665877
• 关键词: biological products; biomedical resource; human tissue; immunology; inflammation; proteins; spectrometry

D-chiro-Inositol-containing compounds were abundant in common laboratory animal feed. By gas chromatography-mass spectrometry (GC/MS) of 6 N HCI hydrolysates, Purina Roden Chow 5001 contained 0.23% of D-chiro-inositol by weight. The principal sources were alfalfa and soybean meal whereas other chow ingredients had less than 2% as much per gram as these legumes. Only traces of L-chiro-inositol were found. D-chiro-Inositol was present in a water-soluble non-ionic form of which most was shown to be pinitol, 1D-3-O-methyl-chiro-inositol. More than 98% of the D-chiro-Inositol fed to rats as Purina Rodent Chow 5001 as well as purified pinitol and deuterated D-chiro-Inositol tracer was absorbed from the gastrointestinal tract. Rats chronically ingesting the chow diet consumed 921 (mol of total D-chiro-inositol/kg/day and excreted less than 5% of that amount in the stool and urine suggesting that the bulk was metabolized. However, even though urinary excretion of total D-chiro-i nositol was very small compared to intake, it declined further by over 98% in response to a chiro-inositol-deficient diet. Thus, urinary levels may reflect dietary intake. Recent reports have shown that D-chiro-inositol is found in certain putative insulin mediator fractions and that increased urinary excretion occurs in uncontroleld diabetes mellitus. Further work is needed to clarify the dietary and potential nutritive role of D-chiro-inositol.

D-Chiro-耶罗醇的化合物的共同点很丰富 实验室动物饲料。 通过气相色谱 - 质谱法 （GC/MS）6 N HCI水解液，Purina Roden Chow 5001包含 d-chiro肌醇的0.23％按重量。 主要来源是 苜蓿和大豆餐，而其他食物成分少于 每克的2％与这些豆类一样多。 只有l-chiro肌醇的痕迹 被发现。 D-Chiro-肌醇存在于水溶性的非离子化中 大多数形式被证明是Pinitol， 1d-3-O-甲基chiro肌醇。 超过98％的D-Chiro肌醇 喂给大鼠，如purina啮齿动物盘5001以及纯化的皮醇和 氘化的D-Chiro肌醇示踪剂被从中吸收 胃肠道。 大鼠长期摄入食物饮食 消耗921（摩尔总d-chiro-肌醇/kg/day，排泄物较少 粪便和尿液中的5％表明散装 被代谢。 但是，即使总尿液排泄 与摄入量相比，D-Chiro-i Nositol非常小 进一步以超过98％的响应，以响应chiro尼苏醇缺乏饮食。 因此，尿液水平可能反映了饮食摄入量。 最近的报告有 表明在某些推定的胰岛素中发现了D-Chiro肌醇 介质分数和增加的尿液排泄发生在 无控制的糖尿病。 需要进一步的工作来澄清 D-Chiro肌醇的饮食和潜在营养作用。