DOSE EFFECTS OF DIETARY PHYTOSTEROLS ON CHOLESTEROL METABOLISM: A CONTROLLED

膳食植物甾醇对胆固醇代谢的剂量效应：对照

• 批准号: 8361452
• 负责人: RICHARD E. OSTLUND
• 金额: $ 1.08万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8361452
• 关键词: Adult; Beverages; Cholesterol; Cholesterol Homeostasis; Diet; Dose; Eating; Education; Excretory function; Funding; Grant; Intake; Intestines; LDL Cholesterol Lipoproteins; Lipoproteins; Mass Spectrum Analysis; Measures; Metabolic; National Center for Research Resources; Phytosterols; Placebo Control; Principal Investigator; Research; Research Infrastructure; Resources; Serum; Site; Source; Supplementation; Tracer; United States National Institutes of Health; biomedical resource; cholesterol absorption; cost; feeding; primary outcome; programs; stable isotope

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. BACKGROUND: Phytosterol supplementation of 2 g/d is recommended by the National Cholesterol Education Program to reduce LDL cholesterol. However, the effects of different intakes of phytosterol on cholesterol metabolism are uncertain. OBJECTIVE: We evaluated the effects of 3 phytosterol intakes on whole-body cholesterol metabolism. DESIGN: In this placebo-controlled, crossover feeding trial, 18 adults received a phytosterol-deficient diet (50 mg phytosterols/2000 kcal) plus beverages supplemented with 0, 400, or 2000 mg phytosterols/d for 4 wk each, in random order. All meals were prepared in a metabolic kitchen; breakfast and dinner on weekdays were eaten on site. Primary outcomes were fecal cholesterol excretion and intestinal cholesterol absorption measured with stable-isotope tracers and serum lipoprotein concentrations.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 背景：国家胆固醇教育计划建议每天补充2 g植物甾醇以降低LDL胆固醇。然而，不同植物甾醇摄入量对胆固醇代谢的影响尚不确定。 目的：我们评估了3种植物甾醇摄入量对全身胆固醇代谢的影响。 产品设计：在这个安慰剂对照的交叉喂养试验中，18名成年人接受了植物甾醇缺乏的饮食（50毫克植物甾醇/2000千卡）加上饮料补充0，400，或2000毫克植物甾醇/天，每个4周，随机顺序。所有的饭菜都在代谢厨房准备;工作日的早餐和晚餐都在现场吃。主要结果是通过稳定同位素示踪剂和血清脂蛋白浓度测量的粪便胆固醇排泄和肠道胆固醇吸收。