DOSE EFFECTS OF DIETARY PHYTOSTEROLS ON CHOLESTEROL METABOLISM: A CONTROLLED

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 背景：国家胆固醇教育计划建议每天补充2g植物甾醇以降低低密度脂蛋白胆固醇。然而，不同的植物甾醇摄入量对胆固醇代谢的影响尚不确定。 目的：评价3种植物甾醇摄入对全身胆固醇代谢的影响。 设计：在这项安慰剂对照的交叉喂养试验中，18名成年人按随机顺序接受缺乏植物类固醇的饮食(50毫克植物类固醇/2000千卡)和添加0、400或2000毫克植物类固醇的饮料，每种饮料持续4wk。所有的饭菜都是在新陈代谢的厨房里准备的；工作日的早餐和晚餐都在现场吃。主要结果是通过稳定同位素示踪剂和血清脂蛋白浓度测量粪便胆固醇排泄和肠道胆固醇吸收。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. BACKGROUND: Phytosterol supplementation of 2 g/d is recommended by the National Cholesterol Education Program to reduce LDL cholesterol. However, the effects of different intakes of phytosterol on cholesterol metabolism are uncertain. OBJECTIVE: We evaluated the effects of 3 phytosterol intakes on whole-body cholesterol metabolism. DESIGN: In this placebo-controlled, crossover feeding trial, 18 adults received a phytosterol-deficient diet (50 mg phytosterols/2000 kcal) plus beverages supplemented with 0, 400, or 2000 mg phytosterols/d for 4 wk each, in random order. All meals were prepared in a metabolic kitchen; breakfast and dinner on weekdays were eaten on site. Primary outcomes were fecal cholesterol excretion and intestinal cholesterol absorption measured with stable-isotope tracers and serum lipoprotein concentrations.