PLATELET-ACTIVATING FACTOR AND METASTASIS: CALCIUM-INDEPENDENT PHOSPHOLIPASE

血小板激活因子和转移：钙非依赖性磷脂酶

• 批准号: 8361461
• 负责人: JACKI KORNBLUTH
• 金额: $ 0.4万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8361461
• 关键词: Breast Cancer Cell; Calcium; Development; Funding; Grant; Injection of therapeutic agent; Knockout Mice; Mammary gland; Mass Spectrum Analysis; Metastatic Neoplasm to the Lung; National Center for Research Resources; Neoplasm Metastasis; Phospholipase A2; Phospholipases A; Platelet Activating Factor; Principal Investigator; Research; Research Infrastructure; Resources; Source; United States National Institutes of Health; biomedical resource; cost

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. We determined the contribution of Group VIA Phospholipase A2 (iPLA2¿) to lung metastasis development after injection of E0771 breast cancer cells into the mammary pads of wild type (WT) and iPLA2¿ knockout (iPLA2¿-KO) mice.

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 我们将E0771乳腺癌细胞注射到野生型(WT)和iPLA2基因敲除(iPLA2？-KO)小鼠的乳房垫中，以确定磷脂酶A2组(iPLA2？)在肺转移发展中的作用。