IDENTIFICATION OF THE PHYSIOLOGICALLY RELEVANT ENDOGENOUS LIGAND FOR PPAR?

PPAR 的生理相关内源性配体的鉴定？

• 批准号: 8361385
• 负责人: Manu V. Chakravarthy
• 金额: $ 0.81万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8361385
• 关键词: Disease; Fatty-acid synthase; Funding; Gene Expression; Generations; Grant; Human; Ligands; Mass Spectrum Analysis; National Center for Research Resources; Nuclear Receptors; PPAR alpha; Peroxisome Proliferator-Activated Receptors; Pharmaceutical Preparations; Principal Investigator; Research; Research Infrastructure; Resources; Source; United States National Institutes of Health; biomedical resource; cost; lipid metabolism

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The nuclear receptor PPARalpha is activated by drugs to treat human disorders of lipid metabolism. Its endogenous ligand is unknown. PPARalpha-dependent gene expression is impaired with inactivation of fatty acid synthase (FAS), suggesting that FAS is involved in generation of a PPARalpha ligand.

这个子项目是利用这些资源的众多研究子项目之一