MYOCARDIAL INSULIN RESISTANCE IS NOT WORSENED BY WELL-CONTROLLED HIV INFECTION

心肌胰岛素抵抗不会因 HIV 感染得到良好控制而恶化

• 批准号: 8361470
• 负责人: KEVIN E YARASHESKI
• 金额: $ 4.07万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8361470
• 关键词: Echocardiography; Funding; Glucose; Grant; HIV; HIV Infections; Image; Insulin; Insulin Resistance; Left Ventricular Dysfunction; Left Ventricular Function; Mass Spectrum Analysis; Metabolic; Metabolism; Methods; Myocardial; Myocardial Ischemia; National Center for Research Resources; Palmitates; Peripheral; Positron-Emission Tomography; Principal Investigator; Research; Research Infrastructure; Resources; Risk; Serum; Source; Tracer; United States National Institutes of Health; biomedical resource; cost; fatty acid metabolism; fatty acid oxidation; men

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The relationship between insulin resistance and increased risk for myocardial ischemia and left ventricular (LV) dysfunction in HIV+ men with peripheral metabolic complications (MC) are established; however the independent effects of MC and HIV infection on myocardial substrate metabolism and their relationship to LV dysfunction are unknown. Objective: To quantify myocardial glucose and fatty acid metabolism and examine the relationship to LV function in HIV+ and HIV-negative men with and without MC. Methods: In 23 HIV+ men with MC+ (HIV+/MC+, 42¿6 yrs), 15 HIV+ men without MC (HIV+/MC-, 41¿6 yrs), 9 HIV-negative men with MC (HIV-/MC+, 33¿5 yrs), and 22 HIV-negative men without MC (HIV-/MC-, 25¿6 yrs), myocardial glucose utilization (GLUT), utilization/serum insulin (GLUT/INS), and fatty acid oxidation and utilization were quantified using 11C glucose, 11C palmitate - and 15O-tracers and myocardial positron emission tomography (PET) imaging. LV function was quantified using echocardiography.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其他NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 在HIV+男性外周代谢并发症（MC）患者中，胰岛素抵抗与心肌缺血和左心室（LV）功能障碍风险增加之间的关系已经确立;然而，MC和HIV感染对心肌底物代谢的独立影响及其与LV功能障碍的关系尚不清楚。目的：定量心肌葡萄糖和脂肪酸代谢，并检查与左室功能的关系，在HIV阳性和HIV阴性的男性和无MC。研究方法：在23名感染MC+的HIV+男性中（HIV+/MC+，42 - 6岁），15名HIV+男性，无MC（HIV+/MC-，41 - 6岁），9例HIV阴性男性MC（HIV-/MC+，33 - 5岁），22例HIV阴性男性无MC（艾滋病毒-/MC-，25岁）6岁），心肌葡萄糖利用率（GLUT），利用率/血清胰岛素（GLUT/INS），脂肪酸氧化和利用定量使用11 C葡萄糖，11 C棕榈酸和15 O-示踪剂和心肌正电子发射断层扫描（PET）成像。使用超声心动图量化LV功能。