STRUCTURAL STUDIES OF HUMAN SERYL-TRNA SYNTHETASE IN ANGIOGENESIS

人丝氨酰 TRNA 合成酶在血管生成中的结构研究

• 批准号: 8362422
• 负责人: XIANGLEI YANG
• 金额: $ 0.03万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-03-01 至 2012-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8362422
• 关键词: Affect; Age related macular degeneration; Amino Acyl-tRNA Synthetases; Blindness; Blood Vessels; Complex; Coronary Arteriosclerosis; Development; Enzymes; Funding; Grant; Health; Human; Ligase; Link; Malignant Neoplasms; National Center for Research Resources; Pathway interactions; Play; Principal Investigator; Psoriasis; Radiation; Regulation; Research; Research Infrastructure; Resources; Rheumatoid Arthritis; Role; Serine-tRNA Ligase; Signal Pathway; Source; Structure; United States National Institutes of Health; VEGFA gene; Vascular Endothelial Growth Factor Receptor-2; angiogenesis; chronic stroke; cost; diabetic; structural biology

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Human seryl-tRNA synthetase(SerRS), a class II aminoacyl?tRNA synthetase and an essential enzyme of the translational pathway, was found to be associated with in vascular development and angiogenesis. The body?s loss of control over angiogenesis causes more than 70 major health conditions affecting over one billion people worldwide. Insufficient formation of new blood vessels (angiogenesis) is connected to coronary artery disease, stroke, and chronic wounds. On the other hand, excessive angiogenesis is also detrimental, and linked to conditions such as cancer, diabetic blindness, age-related macular degeneration, rheumatoid arthritis, and psoriasis. Recently, SerRS was found to play an essential role in angiogenesis through VEGFA/VEGFR2 signal pathways. The crystal structures of human SerRS, and of SerRS in complex with its potential interaction partners would provide important mechanistic understandings of a tRNA synthetase in angiogenesis regulation.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 人丝氨酰-tRNA合成酶（SerRS），一种II类氨酰？tRNA合成酶是翻译途径中的一种必需酶，与血管的发育和血管生成有关。尸体？血管生成失控导致70多种主要健康状况，影响全球10亿多人。新血管形成不足（血管生成）与冠状动脉疾病、中风和慢性伤口有关。另一方面，过度的血管生成也是有害的，并且与诸如癌症、糖尿病性失明、年龄相关性黄斑变性、类风湿性关节炎和牛皮癣的病症有关。近年来，研究发现SerRS通过VEGFA/VEGFR 2信号通路在血管生成中发挥重要作用。人类SerRS的晶体结构，以及SerRS与其潜在的相互作用伙伴的复合物的晶体结构，将提供重要的tRNA合成酶在血管生成调控中的机制理解。